CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
黑色素瘤过继性 T 细胞治疗：对外科实践的影响及外科医生的作用
英文原题：Adoptive T-Cell Therapy in Melanoma: How This Will Impact Surgical Practice and the Role of Surgeons.
查看英文原题
Adoptive T-Cell Therapy in Melanoma: How This Will Impact Surgical Practice and the Role of Surgeons.
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中文摘要
黑色素瘤是少数几种对部分转移性患者明确可通过手术获益的癌症之一。然而，在免疫检查点阻断时代，手术治疗转移性黑色素瘤的作用尚未明确界定。过继细胞疗法，包括TIL（肿瘤浸润淋巴细胞）和CAR-T 细胞，通常需要转移瘤切除术以获取制备个体化细胞产品所需的肿瘤特异性免疫细胞和/或抗原。因此，外科医生必须熟练掌握适当组织的获取技术，并了解组织递送要求，以确保恰当的术前规划和术后恢复。
展开英文摘要原文
Melanoma is one of a small number of cancers where there is a clear role for surgery in selected patients with metastatic disease.
However, the role of surgery for metastatic melanoma in the age of immune checkpoint blockade is not clearly delineated. Adoptive cell therapies, which include tumor-infiltrating lymphocytes and chimeric antigen receptor T cells, often require metastasectomy to obtain the tumor-specific immune cells and/or antigens necessary to create personalized cell-based products.
It is, therefore, essential that the surgeon be well-versed in techniques for procuring appropriate tissue and familiar with their delivery to ensure appropriate preoperative planning and postoperative recovery.
论文信息
- 作者
- Chick RC、Beane JD、Contreras CM
- 第一作者单位
- Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USA.United States
- 通讯作者单位
- Division of Surgical Oncology, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210, USA. Electronic address: carlo.contreras@osumc.edu.United States
- 文献类型
- 综述
- 期刊
- Surgical oncology clinics of North America2025 Jul
- 原文标识
- PubMed 40413008 · DOI 10.1016/j.soc.2025.01.002