CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Tissue-resident immune cells in cervical cancer: emerging roles and therapeutic implications.
Tissue-resident immune cells in cervical cancer: emerging roles and therapeutic implications.
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“热”肿瘤的良好预后在肿瘤学中已被广泛认可。近年来，三级淋巴结构（TLS）的概念使人们对肿瘤组织内的局部免疫细胞有了新的认识。组织驻留免疫细胞是新发现的一类TIL（肿瘤浸润淋巴细胞）亚群，由于其能够在组织内长期驻留并对局部抗原产生有效应答，正逐渐被认为是肿瘤浸润和TLS形成中的潜在关键角色。宫颈癌（CC）是全球女性癌症相关死亡的第四大常见原因，与其他恶性肿瘤相比，其在阐明肿瘤免疫微环境方面的进展相对有限。值得注意的是，组织驻留免疫细胞在CC微环境中的作用仍未得到充分表征。这篇综合性综述旨在整合当前知识并批判性评估这些细胞在CC发病机制中的推定作用，为局部肿瘤微环境的复杂动态提供新的见解。
The favorable prognosis of "hot" tumors is widely acknowledged in oncology. Recently, the concept of tertiary lymphoid structures (TLS) has renewed appreciation for local immune cells within tumor tissues. Tissue-resident immune cells, a newly identified subset of tumor-infiltrating lymphocytes, are emerging as potential key players in tumor infiltration and TLS formation, due to their ability to reside indefinitely within tissues and mount effective responses to local antigens.
Cervical cancer (CC), the fourth most common cause of cancer-related mortality among women globally, has experienced comparatively limited progress in delineating its tumor immune microenvironment compared to other malignancies.
Notably, the role of tissue-resident immune cells within the CC milieu remains inadequately characterized. This comprehensive review aims to synthesize current knowledge and critically evaluate the putative roles of these cells in CC pathogenesis, providing new insights on the intricate dynamics of the local tumor microenvironment.
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