肿瘤细胞治疗研究
英文原题：Tumor immune microenvironment in cervical cancer: Histological subtype-specific immune landscapes and therapeutic implications.
Tumor immune microenvironment in cervical cancer: Histological subtype-specific immune landscapes and therapeutic implications.
宫颈癌是全球女性中第四大常见恶性肿瘤，高危型人乳头瘤病毒（HPV）感染被认为是其主要病因。
宫颈癌是全球女性中第四大常见恶性肿瘤，高危型人乳头瘤病毒（HPV）感染被认为是其主要病因。宫颈癌可根据HPV状态分为HPV相关型和非HPV相关型，也可根据组织学分为鳞状细胞癌（SCC）、腺癌（ADC）、腺鳞癌，以及神经内分泌癌、玻璃样细胞癌和胃型ADC等罕见亚型。近年来，单细胞和空间转录组学以及蛋白质组学方法的进展揭示了不同宫颈癌亚型TIME的显著异质性，并突出了免疫细胞及其他影响整体肿瘤免疫应答的因素的作用。TIME的这种异质性可能关键性地影响肿瘤进展、免疫逃逸和整体治疗反应性。因此，本综述总结了宫颈癌主要组织学亚型的免疫特征，重点关注免疫细胞组成、基质结构和代谢影响，旨在提供一种整合性认识，以支持更精细和亚型特异性的治疗策略。
Cervical cancer is the fourth most common malignancy in women worldwide, with high-risk human papillomavirus (HPV) infection recognized as the predominant etiological factor. Cervical cancer can be classified by HPV status, as HPV-associated or non-HPV-associated, and by histology, which includes squamous cell carcinoma (SCC), adenocarcinoma (ADC), adenosquamous carcinoma, and rare subtypes such as neuroendocrine carcinoma, glassy cell carcinoma, and gastric-type ADC. Recent advances in single-cell and spatial transcriptomics, along with proteomic approaches, have revealed marked heterogeneity in the TIME of different cervical cancer subtypes and highlighted the roles of immune cells and other factors that influence the overall tumor immune responses. This heterogeneity in TIME may critically influence tumor progression, immune evasion, and overall therapeutic responsiveness. Therefore, this review summarizes the immune characteristics of the major histological subtypes of cervical cancer, with a focus on immune cell composition, stromal architecture, and metabolic influences, aiming to provide an integrated understanding that supports more refined and subtype-specific treatment strategies.
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