CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
复杂的神经-免疫相互作用塑造胶质瘤免疫治疗
英文原题：Complex neural-immune interactions shape glioma immunotherapy.
查看英文原题
Complex neural-immune interactions shape glioma immunotherapy.
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中文摘要
中枢神经系统（CNS）中丰富的神经与免疫相互作用塑造其功能，并为CNS恶性肿瘤的免疫治疗构建独特的免疫微环境。如今，“中枢神经系统具有免疫豁免特权”这一已被推翻的观点已不再成立；人们认识到，独特的免疫生态位和大脑持续的免疫监视以多种方式促进脑健康，并显著影响CNS癌症的免疫治疗策略。挑战包括脑、免疫细胞和肿瘤细胞之间促进免疫抑制及神经毒性的相互作用。要开发有效的神经系统肿瘤免疫疗法，需要更深入地了解神经细胞、免疫细胞与恶性细胞之间的这些相互作用。本文结合此类独特的神经免疫相互作用，综述脑和脊髓胶质瘤免疫治疗的进展与挑战，并指出优化有前景的胶质瘤免疫疗法所需的后续研究。
展开英文摘要原文
Rich neural-immune interactions in the central nervous system (CNS) shape its function and create a unique immunological microenvironment for immunotherapy in CNS malignancies. Far from the now-debunked concept of CNS "immune privilege," it is now understood that unique immunological niches and constant immune surveillance of the brain contribute in multifaceted ways to brain health and robustly influence immunotherapy approaches for CNS cancers.
Challenges include immune-suppressive and neurotoxicity-promoting crosstalk between brain, immune, and tumor cells. Developing effective immunotherapies for cancers of the nervous system will require a deeper understanding of these neural-immune-malignant cell interactions.
Here, we review progress and challenges in immunotherapy for gliomas of the brain and spinal cord in light of these unique neural-immune interactions and highlight future work needed to optimize promising immunotherapies for gliomas.
论文信息
- 作者
- Song KW、Lim M、Monje M
- 第一作者单位
- Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA.United States
- 通讯作者单位
- Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA; Department of Neurosurgery, Stanford University, Palo Alto, CA, USA; Howard Hughes Medical Institute, Stanford University, Palo Alto, CA, USA. Electronic address: mmonje@stanford.edu.United States
- 文献类型
- 综述
- 期刊
- Immunity2025 May 13
- 原文标识
- PubMed 40324379 · DOI 10.1016/j.immuni.2025.04.017