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多发性骨髓瘤的 CAR-T:实践要点

英文原题:CAR-T for multiple myeloma: practice pearls.

查看英文原题

CAR-T for multiple myeloma: practice pearls.

PubMed 2025/04/17(内容时间) Bone Marrow Transplant Q1 · IF 5.1(JCR 2025)

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中文摘要

嵌合抗原受体(CAR)T细胞产品西达基奥仑赛和伊德基奥仑赛已改变多发性骨髓瘤患者的管理方式。本文提供一份实用指南,介绍将CAR-T 纳入临床实践的要点,内容包括预期结局、转诊时机建议、桥接治疗、治疗并发症、治疗顺序以及复发管理。

展开英文摘要原文

The CAR-T cell products ciltacabtagene autoleucel and idecabtagene vicleucel have transformed the management of patients with multiple myeloma.

Here, we present a practical guide highlighting clinical pearls on the incorporation of CAR-T into clinical practice. Topics addressed include expected outcomes, recommendations for referral timing, bridging therapy, treatment complications, therapeutic sequencing, and management of relapse.

论文信息

作者
O'Leary D、Bachanova V
单位
Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, USA. dholeary@umn.edu.United States
文献类型
综述
期刊
Bone marrow transplantation2025 Jul
原文标识
PubMed 40246942 · DOI 10.1038/s41409-025-02582-6