CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer.
Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer.
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在胰腺癌中，新辅助放化疗可能影响 TILs 和 PD-L1 表达，从而改善免疫抑制微环境，并提示检查点抑制剂与放射治疗之间具有潜在协同作用。
82 例 PDAC 患者接受手术切除，其中 55 例边界可切除 PDAC（BR-PDAC）患者接受 NACRT，另有 27 例可切除 PDAC 患者直接手术、未接受 NACRT。研究者采用免疫组化染色检查切除标本中的 PD-1⁺ TIL（肿瘤浸润淋巴细胞）、CD8⁺ TIL、叉头框蛋白 P3 阳性（Foxp3⁺）TIL，以及肿瘤细胞中的 PD-L1 表达。
PD-L1 高表达与 NACRT 治疗呈正相关，与 PD-1⁺ TIL 呈负相关。CD8⁺ TIL 水平较高与 PD-L1 表达强相关。直接手术组中，PD-1⁺ TIL 和 Foxp3⁺ TIL 数量显著相关，而 NACRT 组中未见此关联。两个组中，患者总生存期均与单独的 PD-1⁺ TIL 或 PD-L1 表达无显著相关性。
胰腺癌 NACRT 可能影响 TIL 和 PD-L1 表达，进而改善免疫抑制性微环境，提示免疫检查点抑制剂与放疗可能具有协同作用。
Eighty-two patients with PDAC underwent surgical resection. Among them, 55 patients with borderline-resectable PDAC (BR-PDAC) received NACRT, while 27 patients with resectable PDAC underwent straightforward resection without NACRT. Using immunohistochemical staining, resected specimens were examined to assess PD-1 + tumor-infiltrating lymphocytes (TILs), CD8 + TIL, forkhead box P3 positive (Foxp3 + ) TILs, and PD-L1 expression in tumor cells.
High PD-L1 expression correlated positively with NACRT treatment and inversely with PD-1 + TILs. A high CD8 + TILs level was strongly correlated to PD-L1 expression. The numbers of PD-1 + TILs and Foxp3 + TILs were significantly correlated in the straight-line group but not in the NACRT group. In both groups, no significant correlation was found between the overall survival of patients and PD-1 + TILs or PD-L1 expression alone.
NACRT in pancreatic cancer may affect TILs and PD-L1 expression, thereby improving the immunosuppressive microenvironment and implying a potential synergy between checkpoint inhibitors and radiation treatment.
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