CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Chimeric antigen receptor T-cell therapy for refractory post-transplant lymphoproliferative disorder after lung transplantation.
Chimeric antigen receptor T-cell therapy for refractory post-transplant lymphoproliferative disorder after lung transplantation.
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CAR-T 细胞疗法(CAR-T)已用于治疗实体器官移植患者的难治性移植后淋巴增殖性疾病(PTLD),患者接受过心脏、肾脏、肝脏、肠道或胰腺移植。本文报告一名 73 岁女性接受 CAR-T 治疗难治性 PTLD 的病例;她在 7 年前因特发性肺纤维化接受了双肺移植。本文讨论该患者的免疫抑制管理、临床病程和治疗结局。
Chimeric antigen receptor T-cell therapy (CAR-T) has been used to treat refractory post-transplant lymphoproliferative disorder (PTLD) in solid organ transplant patients, including heart, kidney, liver, intestine, and pancreas.
We report the use of CAR-T for treating refractory PTLD in a 73-year-old female who was 7 years post bilateral lung transplantation for idiopathic pulmonary fibrosis.
We discuss the immunosuppression management in this patient, as well as her clinical course and outcome.
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