← 返回

CAR-T 细胞治疗肺移植后难治性移植后淋巴增殖性疾病

英文原题:Chimeric antigen receptor T-cell therapy for refractory post-transplant lymphoproliferative disorder after lung transplantation.

查看英文原题

Chimeric antigen receptor T-cell therapy for refractory post-transplant lymphoproliferative disorder after lung transplantation.

PubMed 2024/04/25(内容时间) JHLT Open

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

CAR-T 细胞疗法(CAR-T)已用于治疗实体器官移植患者的难治性移植后淋巴增殖性疾病(PTLD),患者接受过心脏、肾脏、肝脏、肠道或胰腺移植。本文报告一名 73 岁女性接受 CAR-T 治疗难治性 PTLD 的病例;她在 7 年前因特发性肺纤维化接受了双肺移植。本文讨论该患者的免疫抑制管理、临床病程和治疗结局。

展开英文摘要原文

Chimeric antigen receptor T-cell therapy (CAR-T) has been used to treat refractory post-transplant lymphoproliferative disorder (PTLD) in solid organ transplant patients, including heart, kidney, liver, intestine, and pancreas.

We report the use of CAR-T for treating refractory PTLD in a 73-year-old female who was 7 years post bilateral lung transplantation for idiopathic pulmonary fibrosis.

We discuss the immunosuppression management in this patient, as well as her clinical course and outcome.

论文信息

作者
Veit K、Peña T、Klesney-Tait J、Mou E、Farooq U
第一作者单位
University of Nebraska Medical Center, Omaha, Nebraska.
通讯作者单位
University of Iowa Hospitals and Clinics, Iowa City, Iowa.
文献类型
病例报告
期刊
JHLT open2024 Aug
原文标识
PubMed 40143897 · DOI 10.1016/j.jhlto.2024.100101