CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
玻璃体腔注射甲氨蝶呤联合 CAR-T 治疗眼前节 B 细胞急性淋巴细胞白血病复发
英文原题：Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse.
查看英文原题
Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse.
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中文摘要
作者报告一例儿童罕见病例：单侧假性前房积脓和眼压升高是急性淋巴细胞白血病复发的唯一表现。患者接受玻璃体内甲氨蝶呤及CAR-T 细胞治疗，随后达到缓解。本病例表明，玻璃体内甲氨蝶呤可作为 CAR-T 治疗的安全、有效辅助疗法，用于伴眼部受累的复发性急性淋巴细胞白血病。仍需进一步研究 CAR-T 疗法和玻璃体内甲氨蝶呤治疗伴眼部受累急性淋巴细胞白血病的作用。
展开英文摘要原文
The authors present a child with a rare case of unilateral pseudo-hypopyon and raised intraocular pressure as the only manifestation of acute lymphoblastic leukemia recurrence. This was treated with intravitreal methotrexate and chimeric antigen receptor T-cell therapy (CAR-T) with subsequent remission. This case demonstrates intravitreal methotrexate is a safe and effective adjunct to use with CAR-T therapy for relapsing acute lymphoblastic leukemia with ocular involvement.
Further research should be sought on both CAR-T therapy and intravitreal methotrexate for acute lymphoblastic leukemia with ocular involvement. [ J Pediatr Ophthalmol Strabismus . 2025;62(2):e18-e21.] .
论文信息
- 作者
- De Silva C、Connor A、Roberts W
- 文献类型
- 病例报告
- 期刊
- Journal of pediatric ophthalmology and strabismus2025 Mar-Apr
- 原文标识
- PubMed 40125773 · DOI 10.3928/01913913-20250117-01