CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer.
Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer.
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晚期宫颈癌（CC）患者迫切需要新的治疗策略。本文展示了一种新型联合免疫疗法的协同抗CC效应，该疗法采用过继转移的自体Vγ9Vδ2 T细胞和αβ T细胞。研究揭示了循环和肿瘤浸润性Vγ9Vδ2 T细胞在抗CC免疫中的关键作用。重要的是，自体Vγ9Vδ2 T细胞不仅通过直接杀伤肿瘤，还通过抗原呈递促进同基因αβ T细胞的活化和杀瘤活性，从而与αβ T细胞表现出协同抗CC效应，而常规化疗可进一步增强这一效应。此外，Vγ9Vδ2 T细胞可通过竞争性结合BTN3A1恢复αβ T细胞的杀瘤功能，BTN3A1是CC细胞上的一种TCR-Vγ9Vδ2配体，可被活化αβ T细胞来源的IFN-γ上调。这些发现揭示了自体Vγ9Vδ2 T细胞和αβ T细胞在CC免疫治疗中的关键协同效应，并阐明了其潜在机制。
New treatment strategies are urgently needed for patients with advanced cervical cancer (CC).
Here, a synergistic anti-CC effect of a novel combinatorial immunotherapy with adoptively transferred autologous Vγ9Vδ2 T cells and αβ T cells is shown. The pivotal role of both circulating and tumor-infiltrating Vγ9Vδ2 T cells in anti-CC immunity is uncovered.
Importantly, autologous Vγ9Vδ2 T cells show a synergistic anti-CC effect with αβ T cells not only through killing tumor directly, but also by promoting the activation and tumoricidal activity of syngeneic αβ T cells through antigen presentation, which can be further boosted by conventional chemotherapy.
Moreover, Vγ9Vδ2 T cells can restore the tumoricidal function of αβ T cell through competitively binding to BTN3A1, a TCR-Vγ9Vδ2 ligand on CC cells upregulated by IFN-γ derived from activated αβ T cell.
These findings uncover a critical synergistic effect of autologous Vγ9Vδ2 T cells and αβ T cells in immunotherapy of CC and reveal the underlying mechanisms.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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