近红外光激活上转换纳米颗粒/Zn(x)Mn(1-x)S 核壳纳米颗粒以改善乳腺癌治疗

Multimodal combined therapy constitutes an ideal strategy for the treatment of primary tumors and the suppression of distant metastatic tumors. In this study, a 4T1 cell membrane-coated UCNPs@Zn x Mn 1- x S (TUC@ZMS) nanoplatform is designed for synergistic photodynamic (PDT), chemodynamic (CDT), gas, and immune-based cancer therapy.

The 4T1 cell membrane coating enhances tumor-targeting specificity, while TUC@ZMS, under 980 nm near-infrared (NIR) light activation, generates singlet oxygen ( 1 O 2 ) for PDT and induces reactive oxygen species (ROS) via CDT to trigger tumor cell apoptosis. The released Mn 4+ ions are reduced to Mn 2+ in situ , depleting intracellular glutathione (GSH) and further enhancing the efficacy of both PDT and CDT.

Notably, PDT also promotes immunogenic cell death (ICD), while Mn 2+ and H 2 S activate the cGAS-STING pathway, inducing systemic immune responses characterized by infiltration of CD8 + T cells and NK cells. This multimodal therapeutic strategy targets primary breast tumors while effectively inhibiting distant lung metastases.

Overall, TUC@ZMS demonstrates significant potential as a multifunctional nanoplatform for synergistic cancer treatment and immune activation.