RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
破骨细胞和树突状细胞介导的 NK 和 T 细胞扩增及功能活化的不同特征
英文原题：Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells.
查看英文原题
Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells.
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中文摘要
破骨细胞（OCs）和树突状细胞（DCs）诱导NK细胞和T细胞的扩增和功能活化。在比较OCs与DCs诱导的NK细胞活化时，无论是来自健康个体还是癌症患者，OCs诱导的NK细胞扩增和功能活化均显著高于DCs。然而，无论是来自健康个体还是癌症患者，OCs或DCs活化的T细胞在扩增水平和功能活化方面均未见差异。OCs选择性扩增并活化CD8+ T细胞，而DCs则扩增并活化CD4+ T细胞。此外，同种异体和自体OCs均诱导相似水平的NK细胞和T细胞扩增及功能活化。总之，这些发现突出了OCs在扩增和活化NK细胞及CD8+ T细胞细胞毒性效应物中的重要作用，并展示了与DCs效应相比的若干差异。
展开英文摘要原文
Osteoclasts (OCs) and dendritic cells (DCs) induce expansion and functional activation of NK and T cells. When comparing OCs with DC-induced activation in NK cells, OCs induced significantly higher cell expansion and functional activation of NK cells as compared to DCs, either from healthy individuals or those obtained from cancer patients.
However, no differences could be seen in the levels of cell expansion and functional activation in T cells activated by OCs or DCs, either from healthy individuals or those from cancer patients. OCs selectively expanded and activated CD8 + T cells, whereas DCs expanded and activated CD4 + T cells.
In addition, both allogeneic and autologous OCs induced similar levels of cell expansion and functional activation of NK and T cells.
Together, these findings highlighted the essential roles of OCs in expanding and activating the cytotoxic effectors of NK, and CD8 + T cells, and demonstrated several differences when compared to the effect of DCs.
论文信息
- 作者
- Kaur K、Jewett A
- 第一作者单位
- Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA.United States
- 通讯作者单位
- Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA. ajewett@mednet.ucla.edu.United States
- 期刊
- Cancer immunology, immunotherapy : CII2025 Mar 1
- 原文标识
- PubMed 40024920 · DOI 10.1007/s00262-025-03956-x
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