CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
内分泌肿瘤的 CAR-T 治疗：新靶点与联合治疗
英文原题：CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies.
查看英文原题
CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies.
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中文摘要
内分泌恶性肿瘤构成了一组具有多样生物学特征的异质性肿瘤。虽然通常呈惰性，但也包括侵袭性类型，且任何转移迹象均提示复发概率高、对常规治疗反应差。嵌合抗原受体（CAR）-T细胞免疫治疗已成为癌症治疗的一项革命性进展，并在内分泌癌中展现出显著的应用潜力。然而，其在临床应用中显示出有限的有效性，这促使人们探索新的模式。鉴定内分泌癌特异且安全的靶点是建立成功CAR-T 治疗的第一步。多种正在研究的疗法通过不同机制为增强CAR-T 细胞疗效提供了潜在改进。本文中，我们总结了在内分泌癌CAR治疗靶点鉴定方面的最新进展，并概述了联合治疗策略。
展开英文摘要原文
Endocrine malignancies constitute a heterogeneous tumour group with diverse biological characteristics. While typically indolent, they encompass aggressive types and presence of any metastatic sign indicates a high probability of recurrence and a diminished response to conventional therapies. Chimeric antigen receptor (CAR)-T cell immunotherapy has constituted a revolutionary advance in cancer treatment and exhibited significant potential for application in endocrine cancer.
However, limited effectiveness was displayed in clinical application, which necessitates the exploration of novel modalities. Identification of specific and safe targets for endocrine cancer is the initial stage towards establishing a successful CAR-T treatment. Various therapies under investigation offer potential enhancements to CAR T cell efficacy through diverse mechanisms.
Herein, we summarize recent advances in identifying targets of endocrine cancer for CAR therapy and provide an overview of combinatorial approaches.
论文信息
- 作者
- Wang F、Zhang R、Zhou Z、Shi R、Peng F、Xu Y、Yang S、Wang Z
- 第一作者单位
- Department of Otolaryngology-Head and Neck Surgery, Xinyang Central Hospital, Xinyang, Henan, China.China
- 通讯作者单位
- Department of Gynaecology, Xinyang Central Hospital, Xinyang, Henan, China.China
- 文献类型
- 综述
- 期刊
- Frontiers in endocrinology2025
- 原文标识
- PubMed 40007813 · DOI 10.3389/fendo.2025.1517525
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →