CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:From past to present: The evolution of immunotherapy and its modern modalities.
From past to present: The evolution of immunotherapy and its modern modalities.
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免疫疗法正作为一种新颖且可靠的治疗技术出现,用于治疗自身免疫、HIV/AIDS、过敏和癌症等疾病。这种方法通过调节患者的免疫系统发挥作用,激活先天性和体液性分支以对抗危及生命的疾病。免疫疗法的基础始于德国生理学家Emil Von Behring对“血清疗法”的发现和开发,他因对白喉治疗的贡献于1901年获得诺贝尔奖。大约在同一时期,William Coley博士通过开发首个基于免疫的肉瘤治疗方法,将减毒细菌菌株直接注射到患者肿瘤中,从而拓展了癌症治疗领域。随着医学科学的进步,对免疫系统及其组成部分更广泛的理解促成了不同免疫治疗技术的出现。这些包括过继性细胞转移疗法、细胞因子疗法、癌症疫苗和抗体-药物偶联物。本章全面介绍了免疫疗法的历史和当前使用的技术,详细说明了其机制背后的原理以及每种免疫治疗技术所应对的疾病类型。通过考察从早期发现到现代进展的历程,本章强调了免疫疗法对医学科学和患者护理的变革性影响。
Immunotherapy is emerging as a novel and reliable therapeutic technique for treating diseases such as autoimmunity, HIV/AIDS, allergy and cancers. This approach works by modulating the patient's immune system, activating both the innate and humoral branches to combat life-threatening diseases. The foundation of immunotherapy began with the discovery and development of "serum therapy" by German physiologist Emil Von Behring who received the Nobel Prize in 1901 for his contributions to the treatment of diphtheria. Around the same time, Dr. William Coley expanded the field for cancer treatment by developing the first immune based cure for sarcomas using attenuated strains of bacteria injected directly into patient's tumours.
As medical science advanced, a broader understanding of the immune system and its components led to the emergence of different immunotherapeutic techniques. These include adoptive cell transfer therapy, cytokine therapy, cancer vaccines, and antibody-drug conjugates.
The chapter provides a comprehensive understanding of the history and the current techniques used in immunotherapy, detailing the principles behind their mechanisms and the types of diseases tackled by each immunotherapeutic technique. By examining the journey from early discoveries to modern advancements, the chapter highlights the transformative impact of immunotherapy on medical science and patient care.
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