RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
SLC7A11 是宫颈癌中与免疫细胞浸润相关的潜在治疗靶点和预后生物标志物
英文原题：SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer.
查看英文原题
SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer.
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研究概要
SLC7A11 与免疫通路相关，是影响宫颈癌预后的危险因素。我们还探索了 37 种可能使宫颈癌患者获益的药物。
研究思路结论见上方概要
背景
SLC7A11在铁死亡和二硫死亡中均发挥重要作用，这两种过程参与了人类发育和稳态。通过生物信息学分析和体外验证，我们探讨了SLC7A11在宫颈癌中的作用。
方法
从TCGA数据库中，我们分析了SLC7A11的表达谱，并通过体外实验验证了其在宫颈癌中的促进作用。根据SLC7A11表达水平将患者分为两个亚组，并在这两组之间鉴定了差异表达基因（DEGs）。随后通过功能富集分析阐明了SLC7A11的机制。研究了SLC7A11与免疫微环境之间的关联。最后，我们通过oncoPredict探索了潜在药物。
结果
我们的研究结果表明，SLC7A11可作为宫颈癌有价值的预后生物标志物。此外，SLC7A11正向调控宫颈癌细胞的增殖、迁移和侵袭。我们在两个亚组之间鉴定了113个DEGs。功能富集分析显示，这些DEGs与免疫相关通路有关。SLC7A11高表达组显示静息NK细胞、中性粒细胞、M0巨噬细胞和活化肥大细胞的富集程度更高，而SLC7A11低表达组则具有更高水平的静息树突状细胞、静息肥大细胞和滤泡辅助性T细胞。此外，SLC7A11高表达患者的TMB评分更高。最后，我们探索了37种可能改善预后的药物。
展开英文摘要原文
BACKGROUND
SLC7A11 is importantly in both ferroptosis and disulfidptosis which participated in human development and homeostasis. By utilizing bioinformatics and in vitro validation, we explored SLC7A11's role in cervical cancer.
METHODS
From the TCGA database, we analyzed SLC7A11 expression profiles and validated its promoting role in cervical cancer by in vitro. Patients were divided into two subgroups according to SLC7A11 expression levels, and differentially expressed genes (DEGs) were identified between these groups. Then SLC7A11's mechanism was then clarified by function enrichment analysis. The association between SLC7A11 and the immune microenvironment was investigated. Finally, we explore potential drugs by oncoPredict.
RESULTS
Our findings suggest that SLC7A11 could serve as a valuable prognostic biomarker in cervical cancer. Besides, SLC7A11 was positively regulated cervical cancer cells' proliferation, migration and invasion. We identified 113 DEGs between two subgroups. Functional enrichment analysis revealed that these DEGs are linked to immune-related pathways. The SLC7A11 high expression group showed greater enrichment of resting NK cells, neutrophils, M0 macrophages, and activated mast cells, whereas the SLC7A11 low expression group had higher levels of resting dendritic cells, resting mast cells, and follicular helper T cells. Besides, there were higher TMB scores in patients with high SLC7A11 expression. Finally, we explore 37 kinds of drugs may improve prognosis.
CONCLUSION
SLC7A11, correlated with immune pathway, is a risk factor affecting the prognosis of cervical cancer. We also explore 37 kinds of drugs that may benefit cervical cancer patients.
论文信息
- 作者
- Guy MM、Bian T、Sun L、Hao Y、Jiao X、Zhang W、Zhang T、Cui B
- 第一作者单位
- Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.China
- 通讯作者单位
- Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. cuibaoxia@sdu.edu.cn.China
- 期刊
- Discover oncology2025 Feb 6
- 原文标识
- PubMed 39915437 · DOI 10.1007/s12672-025-01888-7
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