CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤学中新兴的毒性
英文原题：Emerging toxicities in oncology.
查看英文原题
Emerging toxicities in oncology.
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研究思路按摘要原文分段
目的
新型抗癌药物通常与客观缓解和无病生存期等改善的结果相关。但使用这些新药，患者、照护者和肿瘤内科医生不得不面对新的毒性，这些毒性与传统化疗的副作用截然不同。本综述的目的是分享关于这些新毒性的现有认识。
结果
我们在此综述其中一些新的毒性，如眼部、心脏、肺部和黏膜皮肤毒性，以及CAR-T 细胞的特定副作用。我们还讨论了一个特定问题，即经济毒性。总结：通过这篇综述，护理人员和肿瘤内科医生将了解这些新的毒性，并能够建立自己的专科医生网络，以提供尽可能最好的支持性护理。
展开英文摘要原文
PURPOSE OF REVIEW: New anticancer drugs often are associated with improved results, such as objective response and disease-free survival.
But with these new drugs, patients, caregivers and medical oncologist have to face new toxicities, quite different from the side effects of conventional chemotherapy. The aim of this review is to share the actual knowledge about these new toxicities. RECENT FINDINGS: We review here some of these new toxicities, as ocular, cardio, lung and mucocutaneous toxicities, as well as specific side effects of CAR-T cells.
We also discuss a specific problem, which is financial toxicity. SUMMARY: With this review, caregivers and medical oncologists will be aware of these new toxicities and able to develop their own network of specialized practitioners to provide the best possible supportive care.
论文信息
- 作者
- Mayeur D
- 单位
- Centre George François Leclerc -1, rue Professeur Marion-21079, Dijon, Cedex, France.France
- 文献类型
- 综述
- 期刊
- Current opinion in oncology2025 Mar 1
- 原文标识
- PubMed 39869041 · DOI 10.1097/CCO.0000000000001122