CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞介导治疗脑肿瘤的分子机制与通路
英文原题：Molecular Mechanisms and Pathways of Mesenchymal Stem Cell-mediated Therapy in Brain Cancer.
查看英文原题
Molecular Mechanisms and Pathways of Mesenchymal Stem Cell-mediated Therapy in Brain Cancer.
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中文摘要
间充质干细胞（MSCs）因其独特的生物学特性，包括归巢至肿瘤部位、调节肿瘤微环境以及发挥抗肿瘤效应的能力，已成为治疗脑癌的一种有前景的治疗手段。本综述深入探讨了MSCs介导的脑癌治疗所涉及的分子机制和通路。我们探索了MSCs激活的、有助于其治疗功效的各种信号通路，例如PI3K/Akt、Wnt/-catenin和Notch通路。此外，我们还讨论了MSCs分泌的外泌体和microRNAs在介导抗肿瘤效应中的作用。本综述还阐述了优化基于MSCs的脑癌治疗所面临的挑战和未来方向，包括与MSC来源、递送方法和潜在副作用相关的问题。通过对这些机制和通路的全面理解，我们旨在强调MSCs作为脑癌可行治疗选择的潜力，并为该领域的未来研究提供指导。
展开英文摘要原文
Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach in the treatment of brain cancer due to their unique biological properties, including their ability to home tumor sites, modulate the tumor microenvironment, and exert anti-tumor effects. This review delves into the molecular mechanisms and pathways underlying MSC-mediated therapy in brain cancer.
We explore the various signalling pathways activated by MSCs that contribute to their therapeutic efficacy, such as the PI3K/Akt, Wnt/ -catenin, and Notch pathways.
Additionally, we discuss the role of exosomes and microRNAs secreted by MSCs in mediating anti-tumor effects. The review also addresses the challenges and future directions in optimizing MSC-based therapies for brain cancer, including issues related to MSC sourcing, delivery methods, and potential side effects. Through a comprehensive understanding of these mechanisms and pathways, we aim to highlight the potential of MSCs as a viable therapeutic option for brain cancer and to guide future research in this field.
论文信息
- 作者
- Singh K、Singh G、Gupta JK、Choudhary AN、Kumar A、Jain D、Sharma MC、Kumar S
- 单位
- Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.India
- 文献类型
- 综述
- 期刊
- Current stem cell research & therapy2025
- 原文标识
- PubMed 39851121 · DOI 10.2174/011574888X341525250116052000