CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗：从肿瘤到自身免疫病的发展、挑战与应用拓展
英文原题：CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity.
查看英文原题
CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity.
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中文摘要
嵌合抗原受体（CAR）-T细胞疗法已迅速成为癌症治疗中的突破性方法，尤其是在血液系统恶性肿瘤方面。然而，CAR-T 细胞疗法在实体瘤中的应用仍面临挑战。本综述总结了CAR-T 技术的发展，强调了CAR-T 细胞疗法在实体瘤中的挑战和解决方案。此外，还讨论了关键创新，包括特化CAR-T、联合疗法以及CAR-Treg、CAR-NK和CAR-M细胞的新用途。除此之外，基于CAR的细胞疗法已将其应用范围从肿瘤学扩展到自身免疫性疾病。我们综述了涉及CAR-T、Car-Treg和CAAR-T细胞疗法在多种自身免疫性疾病中的临床前实验和临床试验。通过强调这些前沿进展，本综述凸显了CAR技术在临床实践中的变革性潜力。
展开英文摘要原文
Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies.
However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technologies, emphasized the challenges and solutions in CAR-T cell therapy for solid tumors. Also, key innovations were discussed including specialized CAR-T, combination therapies and the novel use of CAR-Treg, CAR-NK and CAR-M cells. Besides, CAR-based cell therapy have extended its reach beyond oncology to autoimmune disorders.
We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. By highlighting these cutting-edge developments, this review underscores the transformative potential of CAR technologies in clinical practice.
论文信息
- 作者
- Kong Y、Li J、Zhao X、Wu Y、Chen L
- 单位
- School of Medicine, Shanghai University, Shanghai, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2024
- 原文标识
- PubMed 39850899 · DOI 10.3389/fimmu.2024.1519671
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