RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞疗法：解决实体瘤细胞疗法瓶颈的关键？
英文原题：Natural killer cell therapy: the key to tackle the bottleneck of cell therapies against solid tumor?
查看英文原题
Natural killer cell therapy: the key to tackle the bottleneck of cell therapies against solid tumor?
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摘要
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论文信息
- 作者
- Wu D、Miao H、Ma X、McCormack MP、Huang H、Liu X、Li N
- 第一作者单位
- Clinical Trials Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.China
- 通讯作者单位
- Clinical Trials Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: ncctrials@cicams.ac.cn.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Science bulletin2025 Mar 15
- 原文标识
- PubMed 39818506 · DOI 10.1016/j.scib.2024.12.049