CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞来源外泌体 microRNA 用于肿瘤治疗的研究进展：综述
英文原题：Recent research progress on microRNAs from mesenchymal stem cell-derived exosomes for tumor therapy: A review.
查看英文原题
Recent research progress on microRNAs from mesenchymal stem cell-derived exosomes for tumor therapy: A review.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
间充质干细胞（MSCs）是一类能够分化为多种细胞类型、具有强大复制和更新能力的原细胞。MSCs分泌多种营养因子以调节肿瘤组织的微环境。其抑制或促进肿瘤生长的机制可能与MSC来源的外泌体（MSC-Exo）密切相关。然而，MSC-Exo囊泡在肿瘤中的作用仍存在争议。本文综述了MSCs来源外泌体中的microRNA在治疗肿瘤中的潜在应用。
展开英文摘要原文
Mesenchymal stem cells (MSCs) are a class of protocells that can differentiate into various cell types and have robust replication and renewal capabilities. MSCs secrete various nutritional factors to regulate the microenvironment of tumor tissues. The mechanism by which they inhibit or promote tumor growth may be closely related to MSC-derived exosomes (MSC-Exo).
However, the role of MSC-Exo vesicles in tumors remains controversial. This review discusses the potential applications of microRNAs in exosomes derived from MSCs in treating tumors.
论文信息
- 作者
- Jiang Y、Gao X、Zheng X、Lu Y、Zhang M、Yan W、Pan W、Li H
- 单位
- Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China.China
- 文献类型
- 综述
- 期刊
- Journal of cancer research and therapeutics2024 Dec 1
- 原文标识
- PubMed 39792406 · DOI 10.4103/jcrt.jcrt_540_23