CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
18F-FDG PET/CT 显像在皮肤及肌肉内多发性骨髓瘤中的应用
英文原题：18F-FDG PET/CT Imaging of Cutaneous and Intramuscular Multiple Myeloma.
查看英文原题
18F-FDG PET/CT Imaging of Cutaneous and Intramuscular Multiple Myeloma.
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中文摘要
多发性骨髓瘤的皮肤表现罕见，但与其他髓外表现一样，预后较差。我们报告一例65岁男性，患有免疫球蛋白G κ型多发性骨髓瘤，既往接受过自体干细胞移植。在后续治疗中，他出现多个新的左侧髋部皮肤及皮下肿块。这些病变的活检显示为具有间变性形态的浆细胞肿瘤，证实疾病进展。由于疾病难治，他随后接受了针对这些病变的放疗，并计划进行CAR-T 细胞治疗。
展开英文摘要原文
Cutaneous manifestations of multiple myeloma are rare but, as with other extramedullary manifestations, carry a worse prognosis.
We present the case of a 65-year-old man with immunoglobulin G κ multiple myeloma and prior autologous stem cell transplant. On subsequent therapy, he presented with multiple new cutaneous and subcutaneous left hip masses. Biopsy of these lesions revealed plasma cell neoplasm with anaplastic morphology, confirming progression of disease. He subsequently underwent radiation to these lesions with plans for chimeric antigen receptor T-cell therapy due to refractory disease.
论文信息
- 作者
- Lippold B、Jahromi AH
- 第一作者单位
- From the Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO.United States
- 文献类型
- 病例报告
- 期刊
- Clinical nuclear medicine2025 Feb 1
- 原文标识
- PubMed 39774162 · DOI 10.1097/RLU.0000000000005579