← 返回

固有免疫防御者:肿瘤 NK 细胞免疫治疗综述

英文原题:The innate defenders: a review of natural killer cell immunotherapies in cancer.

查看英文原题

The innate defenders: a review of natural killer cell immunotherapies in cancer.

PubMed 2024/12/23(内容时间) Front Immunol Q1 · IF 7(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

癌症已伴随人类数百年,但已开发的治疗常伴显著毒性和多种副作用。免疫学近期进展揭示了免疫系统抗癌的潜力,并推动免疫疗法出现。本文聚焦自然杀伤(NK)细胞,这类先天免疫效应细胞具有直接杀伤癌细胞的突出能力。文章回顾癌症治疗的历史背景、NK细胞的特性,以及增强其抗肿瘤功能的开发方法,同时指出传统治疗的局限。本文还讨论NK细胞免疫疗法的治疗潜力,强调其相较于其他免疫细胞疗法的独特优势。本综述凸显NK细胞疗法在抗癌领域的广阔前景,以及其辅助和改进现有传统疗法的可能性。

展开英文摘要原文

Cancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence of immunotherapy. This review focuses on Natural Killer (NK) cells, innate immune effectors with a remarkable ability to directly kill cancer cells.

We will explore the historical context of cancer treatment, the nature of NK cells, and the ways they have been developed to enhance their anti-tumor function, highlighting the limitations of conventional therapies.

The therapeutic potential of NK cell-based immunotherapies will also be discussed, emphasizing their unique advantages over other immune cell-based approaches. This review highlights the promising future of NK cell therapies in the fight against cancer and their possible application to assist and improve conventional therapies developed so far.

论文信息

作者
Álvarez-Carrasco P、Maldonado-Bernal C
单位
Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.Mexico
文献类型
综述 · 非美国政府资助研究
期刊
Frontiers in immunology2024
原文标识
PubMed 39763648 · DOI 10.3389/fimmu.2024.1482807