RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:The innate defenders: a review of natural killer cell immunotherapies in cancer.
The innate defenders: a review of natural killer cell immunotherapies in cancer.
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癌症已伴随人类数百年,但已开发的治疗常伴显著毒性和多种副作用。免疫学近期进展揭示了免疫系统抗癌的潜力,并推动免疫疗法出现。本文聚焦自然杀伤(NK)细胞,这类先天免疫效应细胞具有直接杀伤癌细胞的突出能力。文章回顾癌症治疗的历史背景、NK细胞的特性,以及增强其抗肿瘤功能的开发方法,同时指出传统治疗的局限。本文还讨论NK细胞免疫疗法的治疗潜力,强调其相较于其他免疫细胞疗法的独特优势。本综述凸显NK细胞疗法在抗癌领域的广阔前景,以及其辅助和改进现有传统疗法的可能性。
Cancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence of immunotherapy. This review focuses on Natural Killer (NK) cells, innate immune effectors with a remarkable ability to directly kill cancer cells.
We will explore the historical context of cancer treatment, the nature of NK cells, and the ways they have been developed to enhance their anti-tumor function, highlighting the limitations of conventional therapies.
The therapeutic potential of NK cell-based immunotherapies will also be discussed, emphasizing their unique advantages over other immune cell-based approaches. This review highlights the promising future of NK cell therapies in the fight against cancer and their possible application to assist and improve conventional therapies developed so far.
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