CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
革新癌症治疗：揭示 CAR-T 细胞疗法的力量
英文原题：Revolutionizing Cancer Treatment: Unveiling the Power of CAR T-cell Therapy.
查看英文原题
Revolutionizing Cancer Treatment: Unveiling the Power of CAR T-cell Therapy.
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中文摘要
癌症是全球面临的重要健康挑战，造成社会和经济负担。尽管医学不断进步，癌症仍是主要死亡原因之一，预计到2040年负担还会增加。手术、放疗和化疗等传统治疗虽有效，但常伴严重副作用。CAR-T（CAR-T 细胞）疗法是一种根据患者免疫系统特点制定的新型免疫疗法，可直接靶向癌细胞。该疗法起源于20世纪80年代，技术进展已使其疗效提高，但仍存在严重副作用、费用高昂和生产差异等挑战。尽管如此，CAR-T 细胞治疗已取得显著成功，尤其是在血液系统恶性肿瘤中。其用于实体瘤仍属新兴领域，但持续研究显示出良好前景。CAR-T 细胞疗法为抗击癌症带来希望，有望重新定义癌症治疗模式，为全球患者重燃希望。
展开英文摘要原文
Cancer is a significant health challenge worldwide, causing social and economic burdens. Despite advancements in medicine, it remains a leading cause of death and is projected to increase by 2040. While conventional treatments like surgery, radiation, and chemotherapy are effective, they often have severe side effects.
CAR T-cell (chimeric antigen receptor T-cell) treatment is a novel immunotherapy method personalized to the patient's immune system and directly targets cancer cells. It originated in the 1980s, and advancements have made it more effective.
However, challenges remain, such as severe side effects, high costs, and manufacturing variability. Despite these challenges, the treatment with CAR T-cells has shown remarkable success, especially in hematologic malignancies. Though, it is new to solid tumours, ongoing research looks promising. CAR T-cell therapy offers hope for fightingcancer, and it stands poised to redefine cancer treatment paradigms, giving renewed optimism to patients globally.
论文信息
- 作者
- Barjasteh AH、Saebi M、Mahmoudi M、Kheder RK、Hashemy SI、Forouzanfar F、Esmaeili SA
- 单位
- Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Iran
- 文献类型
- 综述
- 期刊
- Current pharmaceutical design2025
- 原文标识
- PubMed 39757684 · DOI 10.2174/0113816128336391241107112957