RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
环状 RNA：肿瘤免疫逃逸的关键参与者
英文原题：Circular RNAs: key players in tumor immune evasion.
查看英文原题
Circular RNAs: key players in tumor immune evasion.
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中文摘要
针对肿瘤抗原的免疫反应在限制肿瘤生长中发挥作用。作为回应，癌细胞发展出多种机制来绕过或击败这些抗肿瘤免疫反应——统称为“肿瘤免疫逃逸”。近期研究表明，一组非编码 RNA，即 circRNA，通过调节 CD8+ T 细胞、调节性 T 细胞、NK 细胞、细胞因子诱导的杀伤细胞或其他免疫细胞的活性，影响肿瘤免疫逃逸的多个方面。理解 circRNA 在这一过程中的作用有助于设计增强免疫系统抗肿瘤能力的新型疗法。本综述概述了 circRNA 在肿瘤免疫逃逸中的不同作用。
展开英文摘要原文
Immune responses against tumor antigens play a role in confining tumor growth. In response, cancer cells developed several mechanisms to bypass or defeat these anti-tumor immune responses-collectively referred to as "tumor immune evasion".
Recent studies have shown that a group of non-coding RNAs, namely circRNAs affect several aspects of tumor immune evasion through regulation of activity of CD8 + T cells, regulatory T cells, natural killer cells, cytokine-induced killer cells or other immune cells. Understanding the role of circRNAs in this process facilitate design of novel therapies for enhancing the anti-tumor capacity of immune system. This review provides an outline of different roles of circRNAs in the tumor immune evasion.
论文信息
- 作者
- Sanati M、Ghafouri-Fard S
- 第一作者单位
- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Iran
- 通讯作者单位
- Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.Iran
- 文献类型
- 综述
- 期刊
- Molecular and cellular biochemistry2025 Jun
- 原文标识
- PubMed 39754640 · DOI 10.1007/s11010-024-05186-8