CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
将注意力转向肿瘤-宿主界面，并聚焦于胶质母细胞瘤的瘤周异质性
英文原题：Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
查看英文原题
Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
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中文摘要
大约90%的胶质母细胞瘤复发发生在瘤周脑区（PBZ），而PBZ的空间异质性尚未得到充分研究。在本研究中，通过术前影像学从每位患者获取两个PBZ组织和一个肿瘤组织样本。我们使用多种技术评估微环境以及浸润免疫/肿瘤细胞的特征。我们的数据表明，PBZ中存在一个或多个脑血流量较高的区域，我们将其统称为“高脑血流量界面”（HBI）。HBI表现出比“低脑血流量界面”（LBI）更多的新生血管形成。与LBI相比，HBI往往有更多的巨噬细胞和T淋巴细胞浸润。HBI中的肿瘤细胞多于LBI，且这些肿瘤细胞的基因表达谱存在显著差异。HBI可能是手术切除后PBZ靶向治疗的关键区域。
展开英文摘要原文
Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging.
We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques.
Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the "higher cerebral blood flow interface" (HBI). The HBI exhibited more neovascularization than the "lower cerebral blood flow interfaces" (LBI).
The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.
论文信息
- 作者
- Wang F、Dong J、Xu Y、Jin J、Xu Y、Yan X、Liu Z、Zhao H
- 第一作者单位
- Cancer Center, Department of Neurosurgery, Zhejiang Provincial People's Hospital，Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.China
- 通讯作者单位
- Cancer Center, Department of Neurosurgery, Zhejiang Provincial People's Hospital，Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. shaoshanhu421@163.com.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Nature communications2024 Dec 30
- 原文标识
- PubMed 39738017 · DOI 10.1038/s41467-024-55243-5
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