一种 GD（γδ）型的取消文化

T cells represent an 'unconventional' class of CD3+ lymphocytes with unique phenotypical and functional attributes that distinguishes them from their T-cell receptor-expressing counterparts. Studies investigating the roles of T cells in cancer have shown that these cells are indispensable for effective tumor control and their presence within the tumor may be of prognostic significance. Currently, there is significant interest in harnessing T cells for cancer treatment, and research efforts have focused on the development of T-cell-based strategies that are efficacious against cancer.

Several therapeutic approaches using T cells have been described, premised on the expansion of T cells or chimeric antigen receptor T therapy. The potential for broad, unbiased and 'off-the-shelf' applicability in cancer treatment, drives ongoing and future research and methodologies by which T cells can be exploited for therapeutic use. In this review, we will briefly outline the characteristics of T cells and describe how these work within and promote proper functioning of the cancer-immunity cycle.

Additionally, we will introduce strategies that are less commonly described and may potentially be more efficacious than other types of therapy.

Our discussion will expand upon presently known applications and even highlight the versatility of this immune subset as cancer therapeutics. T-cell-based treatment is an emerging strategy and should be considered for cancelling cancer.