帕博利珠单抗联合二甲双胍治疗转移性头颈部癌的 II 期可行性研究
A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer.
二甲双胍联合帕博利珠单抗耐受性良好，仅出现轻度胃肠道不良事件，并展现出有前景的活性，值得在随机试验中进一步研究。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
头颈部原发性和肺转移性腺样囊性癌中的异质性免疫景观和巨噬细胞动态
英文原题：Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck.
查看英文原题
Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck.
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研究概要
原发性和肺转移性 ACC 表现出异质性的肿瘤免疫微环境。肺转移灶中较高的免疫细胞浸润被抑制性肿瘤相关巨噬细胞的存在所抵消，这可能限制了有效的抗肿瘤反应。
研究思路结论见上方概要
背景
复发或转移性头颈部腺样囊性癌（ACC）罕见且高度侵袭性。由于免疫检查点治疗无效，本研究旨在探讨原发肿瘤组织和肺转移组织的肿瘤免疫微环境，并理解免疫治疗面临的挑战。
方法
我们分析了RNA测序数据，并从25个原发肿瘤和34个肺转移灶构建了免疫图谱。随后通过免疫组织化学和单细胞测序分析对数据进行了验证。
结果
与癌旁正常组织相比，原发性和肺转移性ACC均表现出低免疫浸润。肺转移灶具有更高的免疫浸润水平和抗原呈递评分，但同时具有更高的T细胞排斥和功能障碍评分。单细胞测序数据和免疫组织化学显示，肺转移灶中存在丰富的免疫抑制性肿瘤相关巨噬细胞。M2巨噬细胞浸润高的患者肺转移无生存期更短。
展开英文摘要原文
METHODS
We analyzed RNA sequencing data and constructed immune landscapes from 25 primary tumors and 34 lung metastases. The data were then validated by immunohistochemistry and single-cell sequencing analysis.
RESULTS
Compared to adjacent normal tissues, both primary and lung metastatic ACC showed low immune infiltration. Lung metastases had higher immune infiltration levels and antigen presentation scores but also higher T cell exclusion and dysfunction scores. Single-cell sequencing data and immunohistochemistry revealed abundant immunosuppressive tumor-associated macrophages in lung metastases. Patients with high M2 macrophage infiltration had shorter lung metastasis-free survival. DISCUSSION: Primary and lung metastatic ACC exhibit heterogeneous tumor immune microenvironments. Higher immune cell infiltration in lung metastases is countered by the presence of suppressive tumor-associated macrophages, which may limit effective anti-tumor responses.
论文信息
- 作者
- Wang X、Ma T、Liu H、Zhang S、Yang G、Zhao Y、Kong L、Gao R
- 单位
- Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Frontiers in immunology2024
- 原文标识
- PubMed 39697346 · DOI 10.3389/fimmu.2024.1483887
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