RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
打破常规：非常规 T 细胞在癌症治疗中的应用
英文原题：Breaking the mold: Unconventional T cells in cancer therapy.
查看英文原题
Breaking the mold: Unconventional T cells in cancer therapy.
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中文摘要
非常规T细胞，包括恒定自然杀伤T（iNKT）细胞、γδ T细胞和黏膜相关恒定T（MAIT）细胞，在固有免疫和适应性免疫中均发挥重要作用。这些细胞能迅速对肿瘤作出反应并影响肿瘤微环境（TME）。近年来，对其生物学的理解以及新型治疗方法的开发取得的进展，凸显了它们在癌症免疫治疗中的潜力。本评论将评估该领域的这些进展及转化可能性。
展开英文摘要原文
Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy. This commentary will assess these advances and translational possibilities in the field.
论文信息
- 作者
- Li YR、Zhou K、Zhu Y、Halladay T、Yang L
- 第一作者单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.United States
- 通讯作者单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@ucla.edu.United States
- 文献类型
- 综述
- 期刊
- Cancer cell2025 Mar 10
- 原文标识
- PubMed 39672171 · DOI 10.1016/j.ccell.2024.11.010