通过靶向肿瘤相关巨噬细胞的嵌合受体工程化溶瘤病毒重振内源性抗肿瘤免疫
Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions.
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions.
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癌症免疫治疗的发展和完善是癌症治疗的一项重大进步。针对多种癌症的免疫疗法发现,改变了癌症治疗模式。即便患者疾病复发或难治,免疫治疗仍可延长转移性癌症患者预期寿命。目前正在开发多种治疗方法和药物,以调节免疫系统的不同环节。溶瘤病毒、癌症疫苗、过继细胞疗法、单克隆抗体、细胞因子疗法和免疫检查点抑制剂均已在临床试验中取得成功。现有多种癌症免疫治疗方法,另有多种策略正在临床前和临床阶段测试。免疫治疗已证实有效,也有许多药物和策略被开发以提高疗效。本文旨在全面概述当前用于癌症治疗的免疫疗法,并讨论癌症免疫治疗进展、新兴趋势、局限及潜在未来突破。
A major advance in cancer treatment has been the development and refinement of cancer immunotherapy. The discovery of immunotherapies for a wide range of cancers has revolutionized cancer treatment paradigms. Despite relapse or refractory disease, immunotherapy approaches can prolong the life expectancy of metastatic cancer patients. Multiple therapeutic approaches and agents are currently being developed to manipulate various aspects of the immune system. Oncolytic viruses, cancer vaccines, adoptive cell therapies, monoclonal antibodies, cytokine therapies, and inhibitors of immune checkpoints have all proven successful in clinical trials.
There are several types of immunotherapeutic approaches available for treating cancer, and others are being tested in preclinical and clinical settings. Immunotherapy has proven successful, and many agents and strategies have been developed to improve its effectiveness. The purpose of this article is to present a comprehensive overview of current immunotherapy approaches used to treat cancer. Cancer immunotherapy advancements, emerging patterns, constraints, and potential future breakthroughs are also discussed.
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