CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
淋巴细胞活化基因 3 在肿瘤免疫治疗中的功能、预后生物标志物与治疗潜力
英文原题：Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials.
查看英文原题
Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials.
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中文摘要
淋巴细胞活化基因3（LAG-3）已成为癌症免疫应答调控中的重要免疫检查点。表达LAG-3的T细胞具有抑制作用，可削弱抗肿瘤免疫并促进肿瘤进展。本综述讨论LAG-3在免疫抑制中的功能、其与配体的相互作用，以及其作为癌症预后生物标志物的潜力。我们还探讨靶向LAG-3的治疗策略，包括单克隆抗体、小分子抑制剂和CAR-T 细胞。本综述总结LAG-3相关临床前和临床研究，强调靶向LAG-3的治疗方案有望增强抗肿瘤免疫并改善患者结局。仍需进一步研究充分阐明LAG-3的作用机制，并优化其在肿瘤治疗中的应用。
展开英文摘要原文
Lymphocyte-activation gene 3 (LAG-3) has emerged as a key immune checkpoint regulating immune responses in the context of cancer. The inhibitory effect of LAG-3-expressing T cells contributes to suppressing anti-tumor immunity and promoting tumor progression. This review discusses the function of LAG-3 in immune suppression, its interactions with ligands, and its potential as a prognostic biomarker for cancers.
We also explore therapeutic strategies targeting LAG-3, including monoclonal antibodies, small molecule inhibitors, and CAR T cells. This review summarizes the current preclinical and clinical studies on LAG-3, highlighting the potential of therapeutic regimens targeting LAG-3 to enhance antitumor immunity and improve patients' outcomes.
Further studies are needed to fully elucidate the mechanism of action of LAG-3 and optimize its application in tumor therapy.
论文信息
- 作者
- Ren K、Hamdy H、Meyiah A、Elkord E
- 单位
- Department of Biosciences and Bioinformatics, School of Science, Suzhou Municipal Key Lab in Biomedical Sciences and Translational Immunology, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.China
- 文献类型
- 综述
- 期刊
- Frontiers in immunology2024
- 原文标识
- PubMed 39660130 · DOI 10.3389/fimmu.2024.1501613
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