CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
TP53 突变髓系肿瘤的非移植治疗策略
英文原题：Nontransplant treatment approaches for myeloid neoplasm with mutated TP53.
查看英文原题
Nontransplant treatment approaches for myeloid neoplasm with mutated TP53.
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中文摘要
TP53突变型骨髓增生异常综合征（MDS）和急性髓系白血病（AML）仍是预后不良、治疗困难的克隆性髓系疾病谱。近期研究显示，在AML、MDS及双等位基因TP53缺失的MDS/AML中，TP53突变克隆会成为优势克隆。这些疾病侵袭性强，对多数化疗耐药。2022年最新国际共识分类将其归入“TP53突变型髓系肿瘤”。目前所有治疗方法均未改善此类疾病的生存率。多种新疗法正在开发中，包括CAR-T/NK细胞疗法、突变p53再激活剂、Fc融合蛋白和靶向不同髓系抗原的单克隆抗体。本综述总结TP53突变型髓系肿瘤的当前治疗方法，并概述新兴的非移植治疗策略。
展开英文摘要原文
TP53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) remain a challenging spectrum of clonal myeloid disease with poor prognosis. Recent studies have shown that in AML, MDS, and MDS/AML with biallelic TP53 loss, the TP53-mutated clone becomes dominant. These are highly aggressive diseases that are resistant to most chemotherapies. The latest 2022 International Consensus Classification categorizes these diseases under "myeloid disease with mutated TP53."
All treatment approaches have not improved survival rates for this disease. Many newer therapies are on the horizon, including chimeric antigen receptor T/NK-cell therapies, mutated p53 reactivators, Fc fusion protein, and monoclonal antibodies targeting various myeloid antigens. This review summarizes the current approaches for myeloid disease with TP53 mutation and provides an overview of emerging nontransplant approaches.
论文信息
- 作者
- Mehta AK、Konopleva M
- 第一作者单位
- Department of Hematology and Oncology, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY.
- 通讯作者单位
- Department of Hematology and Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.
- 文献类型
- 综述
- 期刊
- Hematology. American Society of Hematology. Education Program2024 Dec 6
- 原文标识
- PubMed 39644032 · DOI 10.1182/hematology.2024000557
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