CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
T 细胞特征对血液系统恶性肿瘤 CAR-T 细胞治疗的影响
英文原题：Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies.
查看英文原题
Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法改变了血液系统恶性肿瘤的治疗模式。然而，超过半数患者无法实现持续肿瘤控制，部分原因是CAR-T 细胞清除肿瘤细胞的效力不足。T细胞是抗肿瘤免疫应答的关键组成，T细胞内在的多种特征会显著影响CAR-T 疗法结局。本文综述影响CAR-T 疗效的T细胞特征研究进展，包括T细胞耗竭、记忆亚群、衰老、调节性T细胞、CD4+与CD8+ T细胞比值、代谢及T细胞受体库。全面理解成功CAR-T 治疗背后的生物学过程，将有助于进一步优化这些新型治疗方式，提高患者治疗效力和安全性。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies.
However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy.
Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4 + to CD8 + T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.
论文信息
- 作者
- Tao Z、Chyra Z、Kotulová J、Celichowski P、Mihályová J、Charvátová S、Hájek R
- 第一作者单位
- Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic.Czechia
- 通讯作者单位
- Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic. roman.hajek@fno.cz.Czechia
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Blood cancer journal2024 Dec 3
- 原文标识
- PubMed 39627220 · DOI 10.1038/s41408-024-01193-6
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