CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
趋化因子与细胞因子在前列腺癌骨转移中的作用
英文原题：Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis.
查看英文原题
Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis.
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中文摘要
综述目的：前列腺癌（PCa）一旦发生骨转移，预后会显著恶化。调控骨转移的确切机制仍不明确。本综述探讨细胞因子和趋化因子参与骨转移过程的近期研究发现。 近期发现：文章讨论细胞因子在PCa骨转移中的作用，包括调控肿瘤生长、侵袭、骨重塑、血管生成及免疫。当前认识的重要进展涉及免疫逃逸、免疫检查点阻断、肿瘤相关巨噬细胞（TAM）、CAR-T 细胞、细胞因子对基质金属蛋白酶的调节，以及IL-10、IL-27、干扰素、前列腺跨膜蛋白雄激素诱导1（Pmepa1）等细胞因子和分子。此外，细胞因子对RUNX2转录的调控可支持播散肿瘤细胞（DTC）存活和生长，并促进转移灶形成。综述强调细胞因子在PCa骨转移中的作用复杂，提示可通过干扰癌细胞与微环境之间的相互作用寻找潜在治疗靶点。
展开英文摘要原文
PURPOSE OF REVIEW: Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases. RECENT FINDINGS: We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases.
Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon- , prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development.
The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.
论文信息
- 作者
- Shiozawa Y、Parajuli KR、Pienta K、Taichman R
- 第一作者单位
- Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, 27157, NC, USA. yshiozaw@wakehealth.edu.United States
- 通讯作者单位
- Department of Periodontology, University of Alabama at Birmingham, Birmingham, AL, USA. Russell.Taichman@Tufts.edu.United Kingdom
- 文献类型
- 综述
- 期刊
- Current osteoporosis reports2024 Nov 25
- 原文标识
- PubMed 39585513 · DOI 10.1007/s11914-024-00897-9
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