CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗的长期神经认知影响：将评估整合到护理实践
英文原题：Long-term neurocognitive effects of chimeric antigen receptor T-cell therapy: Integrating assessments into nursing practice.
查看英文原题
Long-term neurocognitive effects of chimeric antigen receptor T-cell therapy: Integrating assessments into nursing practice.
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中文摘要
CAR-T 细胞疗法是一种新兴疗法，其急性神经毒性作用已广为人知。尽管该疗法的长期神经毒性研究不足，但部分治疗后患者确实会出现此类影响。护士可在CAR-T 治疗前后开展评估，以判断神经毒性进展程度。评估应包括主观和客观工具，并了解与较严重认知不良事件相关的风险因素。血液科护士可依据现有研究倡导监测并干预这一尚未满足的临床需求，从而改善患者结局。
展开英文摘要原文
Chimeric antigen receptor t-cell (CAR-T) therapy is a newly evolving therapy with well-known acute neurotoxic effects. While the long-term neurotoxic effects of this therapy are under-researched, they exist in subsets of the post-treatment population. Nurses can focus on assessments before and after CAR-T therapy to determine the degree to which these neurotoxic effects progress.
These assessments include subjective and objective tools, as well as an understanding of risk factors associated with a higher degree of adverse cognitive events. By utilizing current research, hematological nurses can advocate for this unmet need to be monitored and intervened upon to improve patient outcomes.
论文信息
- 作者
- McArthur E
- 单位
- Emma.mcarthur@nshealth.ca.
- 期刊
- Canadian oncology nursing journal = Revue canadienne de nursing oncologique2024 Summer
- 原文标识
- PubMed 39502096 · DOI 10.5737/23688076343293
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →