RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肝细胞癌患者免疫细胞动态及其对经血管抗肿瘤介入治疗效率的影响
英文原题：Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients.
查看英文原题
Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients.
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研究概要
较高的 WBC、淋巴细胞、单核细胞和嗜碱性粒细胞计数在 HCC 介入治疗的有效性中起着至关重要的作用。
研究思路结论见上方概要
目的
本研究探讨经血管抗肿瘤介入治疗对肝细胞癌（HCC）患者免疫细胞动态的影响及其与疾病控制和PFS的相关性。
方法
单中心观察性病例对照研究纳入119例HCC患者。根据患者个体化评估实施经血管抗肿瘤介入治疗。在首次治疗前及治疗后28天内采集外周血样本，分析淋巴细胞亚群及其他免疫细胞。
结果
较高的总白细胞（WBC）、淋巴细胞、单核细胞和嗜碱性粒细胞计数与疾病控制率显著相关。亚组分析显示，异常BMI、糖尿病、感染和多发病灶与T细胞异常显著相关。年龄、异常BMI、高血压和异常AFP与总T细胞异常相关。NK细胞、B细胞、Th细胞、Tc/Ts细胞和CD4/CD8比值在PFS概率上未显示显著差异。
展开英文摘要原文
OBJECTIVE
This study investigates the impact of transvascular antitumor interventional therapies on immune cell dynamics and its correlation with disease control and progression-free survival (PFS) in hepatocellular carcinoma (HCC) patients.
METHODS
A single-center observational case-control study was conducted with 119 HCC patients. Transvascular antitumor interventional therapy were administered based on patient-specific evaluations. Peripheral blood samples were collected before and within 28 days after the first treatment to analyze lymphocyte subsets and other immune cells.
RESULTS
Higher counts of total white blood cells (WBCs), lymphocytes, monocytes, and basophils were significantly associated with disease control rate. Subgroup analysis revealed that abnormal BMI, diabetes, infection, and multiple lesions were significantly associated with T cell abnormalities. Age, abnormal BMI, hypertension, and abnormal AFP were linked to total T cell abnormalities. NK cells, B cells, Th cells, Tc/Ts cells, and CD4/CD8 ratios did not show significant differences in PFS probabilities.
CONCLUSION
Higher counts of WBCs, lymphocytes, monocytes, and basophils, play a crucial role in the effectiveness of HCC interventional therapy.
论文信息
- 作者
- Sun YD、Zhang H、Li YM、Zhou CX、Han JJ
- 单位
- Department of Interventional Radiology, Shandong Cancer Hospital and Institute Affiliated Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.China
- 文献类型
- 观察性研究
- 期刊
- Frontiers in immunology2024
- 原文标识
- PubMed 39439786 · DOI 10.3389/fimmu.2024.1450525
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