CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
体外细胞因子吸附作为免疫效应细胞相关神经毒性综合征的治疗选择
英文原题：Extracorporeal cytokine adsorption as therapeutic option for immune effector cell-associated neurotoxicity syndrome.
查看英文原题
Extracorporeal cytokine adsorption as therapeutic option for immune effector cell-associated neurotoxicity syndrome.
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中文摘要
随着接受CAR-T 细胞治疗的患者数量不断增加，重症医学科医生和神经科医生对该疗法并发症的治疗日益关注。我们在一名患有免疫效应细胞相关神经毒性综合征的患者中，将体外细胞因子吸附作为附加治疗。白细胞介素-6水平作为一种通常用于评估疾病进程的易得参数，通过该方法迅速降低。患者完全康复，且仍处于血液学缓解状态。
展开英文摘要原文
With the rising number of patients receiving chimeric antigen receptor T-cells, the treatment of this therapy's complications is of growing concern to intensivists and neurologists.
We used extracorporeal cytokine adsorption as an add-on therapy in a patient suffering from immune effector cell-associated neurotoxicity syndrome. Interleukin-6 level, which as a readily available parameter is generally used to evaluate course of disease, was rapidly reduced using this method. The patient made a full recovery and is still in hematological remission.
论文信息
- 作者
- Buhlmann A、Rom E、Schweiger G、Schneidawind D、David S
- 第一作者单位
- Institute of Intensive Care Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.Switzerland
- 通讯作者单位
- Institute of Intensive Care Medicine, University Hospital Zurich, Rämistrasse 100, Zurich, 8091, Switzerland. sascha.david@usz.ch.Switzerland
- 文献类型
- 病例报告
- 期刊
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025 Jan
- 原文标识
- PubMed 39417926 · DOI 10.1007/s10072-024-07812-1
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