RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
消除障碍：武装 NK 细胞对抗卵巢癌
英文原题：Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer.
查看英文原题
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer.
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中文摘要
改善肿瘤免疫微环境是提高癌症患者治疗结局的关键策略。Sandoval及其同事证明，铁螯合可增强I型IFN产生，促进NK细胞向肿瘤的迁移和活化，并与化疗药物cisplatin协同作用，在小鼠模型中减少转移性卵巢癌进展。参见Sandoval等人的相关文章，第1901页。
展开英文摘要原文
Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901.
论文信息
- 作者
- Bell HN、Zou W
- 单位
- Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.United States
- 期刊
- Cancer discovery2024 Oct 4
- 原文标识
- PubMed 39363745 · DOI 10.1158/2159-8290.CD-24-1012