RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
恒定自然杀伤 T 细胞在实体瘤和血液肿瘤中的预后影响：系统评价和 meta 分析
英文原题：Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis.
查看英文原题
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis.
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研究概要
本研究将为 iNKT 细胞与癌症患者生存率相关性的影响以及如何将这些细胞用作这些患者的治疗靶点提供新的见解。
研究思路结论见上方概要
背景
恒定自然杀伤T（iNKT）细胞是一种免疫亚群，据称连接免疫系统的适应性和先天性分支。重要的是，iNKT细胞通过分泌促炎细胞因子，在不同类型的血液系统恶性肿瘤和实体瘤中促进抗肿瘤免疫。因此，利用此类细胞治疗不同类型肿瘤将是癌症免疫治疗的理想候选方案。
目的
评估iNKT细胞在不同类型实体瘤和血液肿瘤中的预后影响。
方法
在系统综述和meta分析中，使用Google Scholar、ScienceDirect、PubMed、Cochrane Central和Scopus等科学数据库系统检索了评估iNKT细胞预后作用的文章。
结果
引人注目的是，分析显示肿瘤内或循环iNKT细胞对所有研究肿瘤患者的生存率均有积极影响，总体效应为合并风险比0.89（95% CI 0.81至0.98；p= 0.01）。所研究的肿瘤之间存在高度统计学异质性，I2 = 87%；p= 0.00001。
展开英文摘要原文
BACKGROUND
Invariant natural killer T (iNKT) cells are an immune subset that purportedly link the adaptive and the innate arms of the immune system. Importantly, iNKT cells contribute to anti-cancer immunity in different types of hematological and solid malignancies by secreting pro-inflammatory cytokines. Therefore, using such cells in treating different type of tumors would be an ideal candidate for cancer immunotherapy.
OBJECTIVE
To assess the prognostic effect of iNKT cells across different types of solid and hematological tumors.
METHODS
In systematic review and meta-analysis, articles assessed the prognostic effect of iNKT cells were systemically searched using the scientific databases including Google Scholar, ScienceDirect, PubMed, Cochrane Central, and Scopus.
RESULTS
Strikingly, the analysis showed the positive impact of intratumoral or circulating iNKT cells on the survival rate in patients with all studied tumors with overall effect of a pooled hazard ratio of 0.89 (95% CI 0.81 to 0.98; p= 0.01). A highly statistical heterogeneity was noted between studied tumor with I2 = 87%; p= 0.00001.
CONCLUSIONS
Taken together, this study would present a new insight into the impact of iNKT cells correlate with caner patients' survival rate and how such cells would be used as a therapeutic target in these patients.
论文信息
- 作者
- Alhamawi RM、Aloufi N、Alamri AF、Altubayli FA、Alsairi RT、Alhamad RA、Alharbi SM、Ankhli ZA
- 文献类型
- 系统综述 · 荟萃分析
- 期刊
- Cancer biomarkers : section A of Disease markers2024
- 原文标识
- PubMed 39302356 · DOI 10.3233/CBM-240069
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