CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向 B 细胞成熟抗原用于复发/难治性多发性骨髓瘤患者的治疗和监测：一项综合性综述
英文原题：Targeting B-cell maturation antigen for treatment and monitoring of relapsed/refractory multiple myeloma patients: a comprehensive review.
查看英文原题
Targeting B-cell maturation antigen for treatment and monitoring of relapsed/refractory multiple myeloma patients: a comprehensive review.
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中文摘要
尽管近年来治疗取得了重大进展，多发性骨髓瘤（MM）仍然是一种无法治愈的疾病，几乎所有患者在治疗过程中都会经历复发/难治性疾病。延长临床反应的持续时间和持久性将需要开发具有新靶点的治疗药物，能够强效且特异性地清除骨髓瘤细胞。B细胞成熟抗原（BCMA）是一种主要表达于恶性浆细胞上的膜结合蛋白，最近已成为治疗MM患者的几种新型治疗药物的靶点。本综述将聚焦于最近获批和目前正在开发的靶向该蛋白的药物，包括双特异性抗体、抗体-药物偶联物和CAR-T 细胞疗法。此外，该蛋白还可作为一种新型血清生物标志物，用于预测MM患者的预后和监测疾病状态；将详细讨论证明BCMA这一用途的研究。
展开英文摘要原文
Despite major therapeutic advancements in recent years, multiple myeloma (MM) remains an incurable disease with nearly all patients experiencing relapsed and refractory disease over the course of treatment. Extending the duration and durability of clinical responses will necessitate the development of therapeutics with novel targets that are capable of robustly and specifically eliminating myeloma cells.
B-cell maturation antigen (BCMA) is a membrane-bound protein expressed predominantly on malignant plasma cells and has recently been the target of several novel therapeutics to treat MM patients. This review will focus on recently approved and currently in development agents that target this protein, including bispecific antibodies, antibody-drug conjugates, and chimeric antigen receptor T-cell therapies.
In addition, this protein also serves as a novel serum biomarker to predict outcomes and monitor disease status for MM patients; the studies demonstrating this use of BCMA will be discussed in detail.
论文信息
- 作者
- Yashar D、Regidor B、Goldwater MS、Bujarski S、Del Dosso A、Berenson JR
- 第一作者单位
- Berenson Cancer Center, West Hollywood, CA, USA.United States
- 通讯作者单位
- Institute for Myeloma & Bone Cancer Research, 9201 Sunset Blvd., West Hollywood, CA 90069, USA.United States
- 文献类型
- 综述
- 期刊
- Therapeutic advances in hematology2024
- 原文标识
- PubMed 39290982 · DOI 10.1177/20406207241275797
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