CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后迁延性 2019 冠状病毒病经序贯多药治疗成功治愈
英文原题：Protracted coronavirus disease 2019 after chimeric antigen receptor-T cell therapy successfully treated with sequential multidrug therapy.
查看英文原题
Protracted coronavirus disease 2019 after chimeric antigen receptor-T cell therapy successfully treated with sequential multidrug therapy.
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中文摘要
一名56岁女性因难治性弥漫大B细胞淋巴瘤接受CD19嵌合抗原受体-T细胞治疗，于2022年4月罹患重型2019冠状病毒病（COVID-19），并接受nirmatrelvir/ritonavir治疗。然而，她在6月出现持续性疲劳、咳嗽和发热。计算机断层扫描显示双肺磨玻璃影（GGO），患者因COVID-19后机化性肺炎接受皮质类固醇治疗。观察到部分改善，但尽管接受皮质类固醇治疗，仍出现新的GGO。严重急性呼吸综合征冠状病毒2基因组分析检测到Omicron变异株BA.1.1.2，该变异株在初次感染时流行。患者被诊断为迁延性COVID-19，并接受remdesivir、molnupiravir、nirmatrelvir/ritonavir和tixagevimab/cilgavimab治疗。这些治疗似乎有助于迁延性COVID-19的改善。
展开英文摘要原文
A 56-year-old woman who received CD19 chimeric antigen receptor-T cell therapy for refractory diffuse large B-cell lymphoma developed severe coronavirus disease 2019 (COVID-19) and was treated with nirmatrelvir/ritonavir in April 2022.
However, she experienced persistent fatigue and cough and fever in June. Computed tomography revealed bilateral ground-glass opacities (GGO), and the patient was treated with corticosteroids for organizing pneumonia after COVID-19. Partial improvement was observed, but new GGO appeared despite corticosteroid therapy.
Genome analysis of severe acute respiratory syndrome coronavirus 2 detected Omicron variant BA. 1. 1. 2, which was prevalent at the time of initial infection. The patient was diagnosed with protracted COVID-19 and was treated with remdesivir, molnupiravir, nirmatrelvir/ritonavir, and tixagevimab/cilgavimab. These treatments appeared to contribute to the improvement of protracted COVID-19.
论文信息
- 作者
- Yamashita M、Higo H、Fujii N、Matsumoto C、Makimoto G、Ninomiya K、Fujii M、Rai K
- 单位
- Department of Allergy and Respiratory Medicine, Okayama University Hospital, Japan.Japan
- 文献类型
- 病例报告
- 期刊
- Respiratory medicine case reports2024
- 原文标识
- PubMed 39286407 · DOI 10.1016/j.rmcr.2024.102104
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