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被误诊为化脓性汗腺炎的罕见肿瘤:连续三例报告

英文原题:Uncommon neoplasms mistakenly diagnosed as hidradenitis suppurativa: Report of three consecutive cases.

查看英文原题

Uncommon neoplasms mistakenly diagnosed as hidradenitis suppurativa: Report of three consecutive cases.

PubMed 2024/09/12(内容时间) Clin Dermatol Q1 · IF 3.5(JCR 2025)

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中文摘要

化脓性汗腺炎(HS)因其与其他多种皮肤疾病和肿瘤在临床上存在重叠,给诊断带来挑战,可能导致误诊。缺乏确定性诊断试验以及组织病理学使用不足,使诊断更加复杂,而近期对 HS 关注度的增加进一步加剧了这一问题。3 例最初被诊断为 HS 并接受治疗的患者,为厘清诊断疑难而接受了临床检查和皮肤活检。这些最初被标记为 HS 的病例,最终分别发现为腋窝异位组织上的乳腺癌、皮肤 gamma-delta T 细胞淋巴瘤以及浸润性鳞状细胞癌。延迟识别导致了错误的治疗和不良结局。本报告强调,对于屈侧伴有或不伴有溃疡的慢性皮肤结节,需要探索其他诊断。及时进行皮肤活检对于准确诊断至关重要。持续开展临床医生教育对于避免在疑难病例中发生误诊至关重要,而组织病理学有助于实现正确诊断。

展开英文摘要原文

Hidradenitis suppurativa (HS) poses diagnostic challenges due to its clinical overlap with various skin conditions and neoplasms, potentially leading to misdiagnoses. The absence of a definitive diagnostic test and infrequent use of histopathology contribute to diagnostic complexities, exacerbated by the recent increased focus on HS. Three cases initially diagnosed and treated as HS underwent clinical work-up and skin biopsies to resolve diagnostic complexities.

Initially labeled as HS, the cases revealed a breast carcinoma on axillary ectopic tissue, a cutaneous gamma-delta T-cell lymphoma, and an infiltrating squamous cell carcinoma. Delayed recognition led to misguided therapies and adverse outcomes.

This report stresses the need to explore alternative diagnoses for chronic skin nodules with or without ulcerations on the flexures. Timely skin biopsies are crucial for accurate diagnoses. Ongoing clinician education is essential to avoid misdiagnosis in challenging cases, in which histopathology aids in reaching a correct diagnosis.

论文信息

作者
Caputo V、Citterio A、Rongioletti F
单位
Department of Surgical Pathology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address: valentinacaputo67@gmail.com.Italy
文献类型
病例报告
期刊
Clinics in dermatology2024 Nov-Dec
原文标识
PubMed 39270809 · DOI 10.1016/j.clindermatol.2024.09.019