RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
探索 KIR3DL2 在肝细胞癌 NK 细胞中的作用及其潜在的预后意义
英文原题：Exploring the role of KIR3DL2 on NK cells in hepatocellular carcinoma and its potential prognostic implications.
查看英文原题
Exploring the role of KIR3DL2 on NK cells in hepatocellular carcinoma and its potential prognostic implications.
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中文摘要
肝细胞癌（HCC）是一种全球范围内高发的恶性肿瘤，复发率高，严重影响预后和生存。本研究旨在通过对原发性和复发性HCC患者肿瘤及癌旁组织进行单细胞测序，识别预后分子标志物。我们分析了原发性和复发性HCC病例肿瘤及癌旁正常组织的单细胞测序数据，比较免疫细胞数量和基因表达谱。复发性HCC患者中表达KIR3DL2的浸润性NK细胞显著减少。拟时序和细胞通讯分析显示，这些KIR3DL2高表达NK细胞处于静息状态，提示NK细胞耗竭和预后不良。外周血NK细胞中KIR3DL2的表达与组织中一致，凸显其作为HCC预后标志物的潜力。
展开英文摘要原文
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy with a high recurrence rate, significantly impacting prognosis and survival.
This study aims to identify prognostic molecular markers using single-cell sequencing of tumors and adjacent tissues in primary and recurrent HCC patients.
We analyzed single-cell sequencing data from tumor and adjacent normal tissues of primary and recurrent HCC cases to compare immune cell quantity and gene expression profiles. Recurrent HCC patients exhibited a significant reduction in infiltrating NK cells expressing KIR3DL2.
Pseudotemporal and cell communication analyses revealed these KIR3DL2 high NK cells were in a quiescent state, suggesting NK cell exhaustion and poor prognosis. KIR3DL2 expression in peripheral blood NK cells correlated with that in tissues, highlighting its potential as a prognostic marker for HCC.
论文信息
- 作者
- Zhu J、Jin A、Pan B、Guo W、Yang W、Wang B
- 单位
- Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.China
- 期刊
- iScience2024 Sep 20
- 原文标识
- PubMed 39262781 · DOI 10.1016/j.isci.2024.110637
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