CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗神经系统肿瘤
英文原题：CAR-T Cells in the Treatment of Nervous System Tumors.
查看英文原题
CAR-T Cells in the Treatment of Nervous System Tumors.
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中文摘要
CAR-T 细胞在血液系统恶性肿瘤中显示出显著疗效，但在实体瘤中应答有限。在实体瘤中，CAR-T 细胞疗法在脑肿瘤中得到了特别多的探索。由于多种因素阻碍了其活性，包括肿瘤抗原异质性、CAR-T 细胞进入脑肿瘤细胞受限、CAR-T 细胞运输和体内持久性有限以及高度免疫抑制性肿瘤微环境的存在，CAR-T 细胞在多种类型的脑肿瘤中显示出有限的临床疗效。尽管有这些考虑，一些近期研究显示GD2-CAR-T 细胞对弥漫性中线胶质瘤和神经母细胞瘤以及CARv3-TEAM-E细胞对胶质母细胞瘤具有良好的抗肿瘤活性。然而，仍需策略来提高CAR-T 细胞在脑肿瘤中的效果，包括具有多抗原靶向的先进CAR-T 细胞设计和联合疗法的整合。
展开英文摘要原文
Chimeric antigen receptor T cells (CAR-Ts) have shown a remarkable efficacy in hematological malignancies but limited responses in solid tumors. Among solid tumors, CAR-T cell therapy has been particularly explored in brain tumors.
CAR-T cells have shown a limited clinical efficacy in various types of brain tumors due to several factors that have hampered their activity, including tumor antigen heterogeneity, the limited access of CAR-T cells to brain tumor cells, limited CAR-T cell trafficking and in vivo persistence and the presence of a highly immunosuppressive tumor microenvironment.
Despite these considerations, some recent studies have shown promising antitumor activity of GD2-CAR-T cells on diffuse midline gliomas and neuroblastomas and of CARv3-TEAM-E cells in glioblastomas.
However, strategies are required to improve the effect of CAR-T cells in brain tumors, including advanced CAR-T cell design with multiple antigenic targeting and incorporation of combination therapies.
论文信息
- 作者
- Testa U、Castelli G、Pelosi E
- 单位
- Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.Italy
- 文献类型
- 综述
- 期刊
- Cancers2024 Aug 22
- 原文标识
- PubMed 39199683 · DOI 10.3390/cancers16162913