CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
重塑肿瘤免疫微环境以改善基于 CAR-T 细胞的肿瘤免疫治疗
英文原题：Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy.
查看英文原题
Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy.
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中文摘要
在许多血液系统恶性肿瘤中，嵌合抗原受体（CAR）T细胞的过继转移已显示出显著成功；然而，仍需进一步改进以优化治疗效果。目前的 CAR-T 疗法对实体瘤治疗尤其不容乐观。肿瘤的免疫抑制微环境影响 CAR-T 细胞，限制治疗的有效性和安全性。因此，增强 CAR-T 细胞浸润能力并解决肿瘤微环境中的免疫抑制反应，可能增强抗肿瘤作用。具体策略包括结构改造 CAR-T 细胞，联合靶向治疗、放疗或化疗。总体而言，监测肿瘤微环境和 CAR-T 细胞状态有助于进一步研究此类策略的可行性并推进 CAR-T 细胞疗法。
展开英文摘要原文
In many hematologic malignancies, the adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated notable success; nevertheless, further improvements are necessary to optimize treatment efficacy. Current CAR-T therapies are particularly discouraging for solid tumor treatment. The immunosuppressive microenvironment of tumors affects CAR-T cells, limiting the treatment's effectiveness and safety.
Therefore, enhancing CAR-T cell infiltration capacity and resolving the immunosuppressive responses within the tumor microenvironment could boost the anti-tumor effect. Specific strategies include structurally altering CAR-T cells combined with targeted therapy, radiotherapy, or chemotherapy.
Overall, monitoring the tumor microenvironment and the status of CAR-T cells is beneficial in further investigating the viability of such strategies and advancing CAR-T cell therapy.
论文信息
- 作者
- Xia X、Yang Z、Lu Q、Liu Z、Wang L、Du J、Li Y、Yang DH
- 第一作者单位
- The Second Clinical Medical School, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.China
- 通讯作者单位
- Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. wshj510515@163.com.China
- 文献类型
- 综述
- 期刊
- Molecular cancer2024 Aug 26
- 原文标识
- PubMed 39187850 · DOI 10.1186/s12943-024-02079-8
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