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临床试验中的新型治疗药物:癌症治疗的新兴方法

英文原题:Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy.

查看英文原题

Novel therapeutic agents in clinical trials: emerging approaches in cancer therapy.

PubMed 2024/08/11(内容时间) Discov Oncol Q3 · IF 2.8(JCR 2025)

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中文摘要

新型治疗药物在临床试验中为对抗这种普遍且具有破坏性的疾病提供了范式转变,癌症治疗领域正处于变革性革命的前夕。尽管手术、放疗和化疗等久经考验的癌症治疗方法很重要,但该疾病仍在不断进化和适应,因此需要新的、更有效的方法。癌症治疗领域目前正在见证大量创新方法的出现。免疫治疗,包括检查点抑制剂、CAR-T 细胞治疗和癌症疫苗,利用宿主的免疫系统选择性靶向和根除恶性细胞,同时尽量减少对正常组织的损害。激酶抑制剂和单克隆抗体等靶向药物的开发使得治疗癌症的方法更加具有针对性且危害更小。在基因组学和分子谱分析的帮助下,“精准医学”根据每位患者独特的遗传构成定制治疗方案,以最大化治疗效果,同时尽量减少不良副作用。表观遗传治疗、代谢干预、放射性药物,以及对具有协同效应的联合治疗日益重视,进一步拓宽了治疗前景。多阶段临床试验对于确定这些新药的安全性和有效性至关重要,使患者能够获得新疗法,同时也推进了科学认识。癌症治疗的未来充满希望,因为人工智能和大数据的整合有可能彻底改变早期检测和预防。研究人员、医疗服务提供者之间的协作以及患者的积极参与,仍然是持续抗击癌症的基石。

总之,癌症治疗领域动态且不断演变的格局为改善治疗结局带来了希望,强调以患者为中心、数据驱动且合乎伦理的方法,是我们共同迈向无癌世界的关键。

展开英文摘要原文

Novel therapeutic agents in clinical trials offer a paradigm shift in the approach to battling this prevalent and destructive disease, and the area of cancer therapy is on the precipice of a trans formative revolution. Despite the importance of tried-and-true cancer treatments like surgery, radiation, and chemotherapy, the disease continues to evolve and adapt, making new, more potent methods necessary. The field of cancer therapy is currently witnessing the emergence of a wide range of innovative approaches. Immunotherapy, including checkpoint inhibitors, CAR-T cell treatment, and cancer vaccines, utilizes the host's immune system to selectively target and eradicate malignant cells while minimizing harm to normal tissue. The development of targeted medicines like kinase inhibitors and monoclonal antibodies has allowed for more targeted and less harmful approaches to treating cancer.

With the help of genomics and molecular profiling, "precision medicine" customizes therapies to each patient's unique genetic makeup to maximize therapeutic efficacy while minimizing unwanted side effects. Epigenetic therapies, metabolic interventions, radio-pharmaceuticals, and an increasing emphasis on combination therapy with synergistic effects further broaden the therapeutic landscape.

Multiple-stage clinical trials are essential for determining the safety and efficacy of these novel drugs, allowing patients to gain access to novel treatments while also furthering scientific understanding. The future of cancer therapy is rife with promise, as the integration of artificial intelligence and big data has the potential to revolutionize early detection and prevention. Collaboration among researchers, and healthcare providers, and the active involvement of patients remain the bedrock of the ongoing battle against cancer.

In conclusion, the dynamic and evolving landscape of cancer therapy provides hope for improved treatment outcomes, emphasizing a patient-centered, data-driven, and ethically grounded approach as we collectively strive towards a cancer-free world.

论文信息

作者
Joshi DC、Sharma A、Prasad S、Singh K、Kumar M、Sherawat K、Tuli HS、Gupta M
第一作者单位
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandar Sindri, Dist., Ajmer, Rajasthan, India. Deepakjoshi024@gmail.com.India
通讯作者单位
Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India. madhugupta98@gmail.com.India
文献类型
综述
期刊
Discover oncology2024 Aug 11
原文标识
PubMed 39127974 · DOI 10.1007/s12672-024-01195-7