CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞膜片将 CAR 分子从细胞储库转移至常规 T 细胞以构建无需基因修饰的新型融合 CAR-T 细胞
英文原题：Cell membrane patches transfer CAR molecules from a cellular depot to conventional T cells for constructing innovative fused-CAR-T cells without necessitating genetic modification.
查看英文原题
Cell membrane patches transfer CAR molecules from a cellular depot to conventional T cells for constructing innovative fused-CAR-T cells without necessitating genetic modification.
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中文摘要
嵌合抗原受体（CAR）是CAR-T 细胞的核心组成。外源CAR分子可在异体T细胞上产生功能作用，促使其活化并发生后续功能改变。本文基于这一生物学原理提出一种新方法：将外源细胞的CAR分子转移至受体T细胞膜上。该过程使受体T细胞能够识别靶抗原并被激活。这些膜片段赋予正常T细胞更强的肿瘤靶向能力，并激活其固有杀伤功能。该方法的效果提出了一种制备非基因改造CAR-T 细胞的途径，也可能适用于其他免疫细胞。
展开英文摘要原文
Chimeric antigen receptor (CAR) serves as the foundational element of CAR-T cells. Exogenous CAR molecules can exert functional effects on allogeneic T cells, leading to their activation and subsequent functional alterations.
Here we show a new method based on this biological principle: the transfer of CAR molecules from exogenous cells to the membrane of receptor T cells. This process facilitates receptor T cell to recognize target antigens and induces their activation. These patches imbued normal T cells with enhanced tumor targeting capabilities and activated their inherent killing functions. This method's efficacy introduces an approach for constructing non-genetically manipulated CAR-T cells and holds potential for application to other immune cells.
论文信息
- 作者
- Hu J、Zhong L、Wang Y、Hu S、Zhang L、Tian Q
- 第一作者单位
- School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.China
- 通讯作者单位
- School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China. tianqc@hznu.edu.cn.China
- 文献类型
- 读者来信
- 期刊
- Experimental hematology & oncology2024 Aug 5
- 原文标识
- PubMed 39103961 · DOI 10.1186/s40164-024-00545-z
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