CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗中的抗原逃逸：机制与克服策略
英文原题：Antigen escape in CAR-T cell therapy: Mechanisms and overcoming strategies.
查看英文原题
Antigen escape in CAR-T cell therapy: Mechanisms and overcoming strategies.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
CAR-T（CAR-T）细胞疗法在治疗血液系统恶性肿瘤和某些实体瘤方面已显示出前景。然而，其疗效往往受到抗原逃逸导致的阴性复发的阻碍。本综述首先阐明了CAR-T 细胞治疗过程中抗原逃逸的机制，包括预先存在的靶抗原阴性肿瘤克隆的富集、抗原基因突变或选择性剪接、抗原加工缺陷、抗原重分布、谱系转换、表位掩蔽以及胞吐作用介导的抗原丢失。此外，我们总结了克服抗原逃逸的各种策略，评估了其优势和局限性，并提出了未来的研究方向。因此，我们旨在为增强CAR-T 细胞疗法的有效性提供有价值的见解。
展开英文摘要原文
Chimeric antigen receptor T (CAR-T) cell therapy has shown promise in treating hematological malignancies and certain solid tumors.
However, its efficacy is often hindered by negative relapses resulting from antigen escape. This review firstly elucidates the mechanisms underlying antigen escape during CAR-T cell therapy, including the enrichment of pre-existing target-negative tumor clones, antigen gene mutations or alternative splicing, deficits in antigen processing, antigen redistribution, lineage switch, epitope masking, and trogocytosis-mediated antigen loss.
Furthermore, we summarize various strategies to overcome antigen escape, evaluate their advantages and limitations, and propose future research directions.
Thus, we aim to provide valuable insights to enhance the effectiveness of CAR-T cell therapy.
论文信息
- 作者
- Lin H、Yang X、Ye S、Huang L、Mu W
- 第一作者单位
- Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei 430030, China.China
- 通讯作者单位
- Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, Hubei 430030, China. Electronic address: muwei@tjh.tjmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2024 Sep
- 原文标识
- PubMed 39098176 · DOI 10.1016/j.biopha.2024.117252