CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于肿瘤治疗的体内 CAR-T 细胞疗法研发进展与挑战
英文原题：Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment.
查看英文原题
Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法已成为癌症治疗中一种突破性的免疫治疗方法。为克服当前体外CAR-T 细胞治疗产品相关的复杂性和高制造成本，近年来已开发出直接在体内产生CAR-T 细胞的替代策略。这些策略涉及通过工程化纳米载体或病毒载体直接输注CAR基因，以在原位生成CAR-T 细胞。本综述全面概述了T细胞靶向原位CAR生成的最新进展。此外，还指出了体内CAR-T 方法相关的挑战以及克服这些问题的潜在策略。
展开英文摘要原文
The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and high manufacturing cost associated with current ex vivo CAR T cell therapy products, alternative strategies to produce CAR T cells directly in the body have been developed in recent years.
These strategies involve the direct infusion of CAR genes via engineered nanocarriers or viral vectors to generate CAR T cells in situ. This review offers a comprehensive overview of recent advancements in the development of T cell-targeted CAR generation in situ.
Additionally, it identifies the challenges associated with in vivo CAR T method and potential strategies to overcome these issues.
论文信息
- 作者
- Bui TA、Mei H、Sang R、Ortega DG、Deng W
- 第一作者单位
- School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia; Whitlam Orthopaedic Research Centre, Ingham Institute for Applied Medical Research, Liverpool, NSW 2170, Australia; School of Clinical Medicine, Faculty of Medicine, University of New South Wales Sydney, Kensington, NSW 2052, Australia.Australia
- 通讯作者单位
- School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia; Graduate School of Biomedical Engineering, ARC Centre of Excellence in Nanoscale Biophotonics, Faculty of Engineering, UNSW Sydney, NSW 2052, Australia. Electronic address: wei.deng@uts.edu.au.Australia
- 文献类型
- 综述
- 期刊
- EBioMedicine2024 Aug
- 原文标识
- PubMed 39094262 · DOI 10.1016/j.ebiom.2024.105266
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →