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晚期黑色素瘤免疫治疗及其联合治疗的最新进展:一篇综述

英文原题:Recent advances in immunotherapy and its combination therapies for advanced melanoma: a review.

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Recent advances in immunotherapy and its combination therapies for advanced melanoma: a review.

PubMed 2024/07/16(内容时间) Front Oncol Q2 · IF 3.4(JCR 2025)

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中文摘要

黑色素瘤的发病率逐年上升,恶性程度高,预后差,其治疗一直备受关注。临床较多应用的免疫治疗有免疫检查点抑制剂、双特异性抗体、肿瘤疫苗、过继细胞转移疗法、溶瘤病毒疗法等。随着技术和试验的不断发展,除免疫单药治疗外,免疫治疗与放疗的联合治疗也显示出惊人的疗效。本文就晚期黑色素瘤免疫单药及联合治疗的研究进展进行综述,以期为晚期黑色素瘤的治疗策略提供新思路。

展开英文摘要原文

The incidence of melanoma is increasing year by year and is highly malignant, with a poor prognosis. Its treatment has always attracted much attention. Among the more clinically applied immunotherapies are immune checkpoint inhibitors, bispecific antibodies, cancer vaccines, adoptive cell transfer therapy, and oncolytic virotherapy.

With the continuous development of technology and trials, in addition to immune monotherapy, combinations of immunotherapy and radiotherapy have shown surprising efficacy. In this article, we review the research progress of immune monotherapy and combination therapy for advanced melanoma, with the aim of providing new ideas for the treatment strategy for advanced melanoma.

论文信息

作者
Xu J、Mu S、Wang Y、Yu S、Wang Z
第一作者单位
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.China
通讯作者单位
Department of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.China
文献类型
综述
期刊
Frontiers in oncology2024
原文标识
PubMed 39081713 · DOI 10.3389/fonc.2024.1400193