CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胃肠道间质瘤的分子特征与免疫微环境：治疗策略的靶点
英文原题：Molecular characteristics and immune microenvironment of gastrointestinal stromal tumours: targets for therapeutic strategies.
查看英文原题
Molecular characteristics and immune microenvironment of gastrointestinal stromal tumours: targets for therapeutic strategies.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
胃肠道间质瘤（GIST）是最常见的间叶性肿瘤，主要起源于胃肠道卡哈尔间质细胞（ICC）。由于放疗和化疗对GIST通常无效，目前主要治疗方式是手术切除，但多数患者并不适合手术。因此，亟需新的治疗策略。以酪氨酸激酶抑制剂（TKI）为代表的靶向治疗，以及以免疫检查点抑制剂和CAR-T 细胞疗法为代表的免疫治疗，为GIST提供了新的治疗选择，并显示出有希望的治疗应答。本综述总结GIST分子分类和免疫微环境，并讨论相应靶向治疗及免疫治疗方案。这些更新的认识可能为未来GIST治疗策略和临床应用提供更多选择。
展开英文摘要原文
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours, arising mainly from the interstitial cells of Cajal (ICCs) of the gastrointestinal tract. As radiotherapy and chemotherapy are generally ineffective for GISTs, the current primary treatment is surgical resection.
However, surgical resection is not choice for most patients.
Therefore, new therapeutic strategies are urgently needed. Targeted therapy, represented by tyrosine kinase inhibitors (TKIs), and immunotherapy, represented by immune checkpoint inhibitor therapies and chimeric antigen receptor T-cell immunotherapy (CAR-T), offer new therapeutic options in GISTs and have shown promising treatment responses.
In this review, we summarize the molecular classification and immune microenvironment of GISTs and discuss the corresponding targeted therapy and immunotherapy options. This updated knowledge may provide more options for future therapeutic strategies and applications in GISTs.
论文信息
- 作者
- Yu Y、Yu M、Luo L、Zhang Z、Zeng H、Chen Y、Lin Z、Chen M
- 单位
- Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China.China
- 文献类型
- 综述
- 期刊
- Frontiers in oncology2024
- 原文标识
- PubMed 39070147 · DOI 10.3389/fonc.2024.1405727
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →