CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
治疗肿瘤的 CAR-T 细胞联合疗法
英文原题：CAR T cell combination therapies to treat cancer.
查看英文原题
CAR T cell combination therapies to treat cancer.
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中文摘要
嵌合抗原受体（CAR）T细胞在某些血液系统恶性肿瘤中已得到有效应用，但肿瘤复发及在实体瘤中疗效有限的问题依然存在。近期研究致力于开发联合治疗方案以改善疗效和安全性。本文对此类联合治疗策略进行全面综述，并对正在进行的临床试验加以探讨。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cells are effectively used in certain hematological malignancies, though tumor relapse and limited success in solid tumors persist. Recent efforts focus on developing combination treatments to enhance outcomes and safety. Here, we provide a comprehensive overview of such combinatorial approaches and a consideration of ongoing clinical trials.
论文信息
- 作者
- Uslu U、Castelli S、June CH
- 第一作者单位
- Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA.United States
- 通讯作者单位
- Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cjune@upenn.edu.United States
- 文献类型
- 综述
- 期刊
- Cancer cell2024 Aug 12
- 原文标识
- PubMed 39059390 · DOI 10.1016/j.ccell.2024.07.002